# US 8,465,764 B2 · Method for preparing a pharmaceutical compound by way of magnetic carbon nanocapsules

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- Number: US 8,465,764 B2
- Document ID: US8465764B2
- Status: Granted
- Kind: B2
- Application number: 11/367,349
- Filed: 2006-03-06
- Published: 2007-05-03
- Granted: 2013-06-18
- Earliest claimed: 2005-03-08
- Assignees: Phytohealth Corporation; Industrial Technology Research Institute
- Applicants: Gan-Lin Hwang; Tsung-Shann Jiang; Shu-Ling Yeh; Hsien-Ming Wu; Shu-Hao Lee; Shih-Jung Tsai
- Inventors: Gan-Lin Hwang; Tsung-Shann Jiang; Shu-Ling Yeh; Hsien-Ming Wu; Shu-Hao Lee; Shih-Jung Tsai
- Web page: https://patentgrep.com/patent/US8465764B2

## CPC

- C01B 32/15: Nano-sized carbon materials
- A61P 35/00: Antineoplastic agents
- B82Y 30/00: Nanotechnology for materials or surface science, e.g. nanocomposites
- B82Y 40/00: Manufacture or treatment of nanostructures
- C01B: NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; {METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C}
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- B82Y: SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES

## Abstract

A method for preparing a pharmaceutical compound by way of magnetic carbon nanocapsules is disclosed. The method comprises steps of: (a) providing a magnetic carbon nanocapsule with C—(COOH)2 group, and Pt cations, to form a complex; (b) collecting the complex from the magnetic carbon nanocapsule; and (c) removing the Pt cations on the complex.

## Claims

### Claim 1

A method for producing a drug selected from the group consisting of cisplatin and dihydrate cisplatin, in a yield of up to 80 mol %, comprising:
(1) reacting magnetic particle-containing carbon nanocapsules having a diameter in the range of 30-40 nm, the magnetic particles comprising Fe, Co, Ni or an alloy thereof, with an effective amount of a reagent to modify the surface of the nanocapsules to provide >C(—COOH)2 functional groups thereon;
(2) reacting said >C(—COOH)2 functional groups with platinum cations to bind the platinum cations to the >C(—COOH)2 functional groups and form stable cis-form platinum complexes on said nanocapsules;
(3) aminating the stable cis-form platinum complex nanocapsules by reacting said nanocapsules with ammonia to form an aminated cis-form platinum nanocapsule complex; and
(4) hydrolyzing the aminated cis-form platinum nanocapsule complex to form cisplatin or dihydrate cisplatin;
wherein the magnetic particle-containing carbon nanocapsule is a polyhedral carbon cluster composed of an outer shell having an enclosed multilayer graphite structure containing the magnetic particles inside; the number of functional groups—COOH is 123 mmol/g; and the surface modifying reagent is diethylbromomalonate.