# US 8,465,762 B2 · Dermal application system for aminolevulinic acid-derivatives

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- Number: US 8,465,762 B2
- Document ID: US8465762B2
- Status: Granted
- Kind: B2
- Application number: 10/502,495
- Filed: 2003-01-16
- Published: 2006-01-26
- Granted: 2013-06-18
- Earliest claimed: 2002-01-23
- Assignees: Photonamic GmbH & Co. KG
- Applicants: Geoffrey Lee; Rolf-Markus Szeimies; Ulrich Kosciessa
- Inventors: Geoffrey Lee; Rolf-Markus Szeimies; Ulrich Kosciessa
- Web page: https://patentgrep.com/patent/US8465762B2

## CPC

- A61K 49/0021: {the fluorescent group being a small organic molecule}
- A61K 9/7023: {Transdermal patches and similar drug-containing composite devices, e.g. cataplasms (galenical aspects of iontophoretic devices A61K9/0009; microneedle arrays A61K9/0021; buccal patches A61K9/006)}
- A61K 31/195: having an amino group
- A61K 41/0061: {5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA}
- A61P 35/00: Antineoplastic agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The invention relates to a dermal application system for aminolevulinic acid-derivatives, i.e. a pressure-sensitive matrix system containing a crystalline aminolevulinic acid derivative.

## Claims

### Claim 1

A dermal application system, which is a self-adhesive matrix system, consisting of aminolaevulinic acid (ALA) salt crystals suspended in a polymer matrix, wherein the polymer matrix consists of polymers from the group consisting of acrylates, silicon polymers, and polyisobutylene, wherein a substantial amount of the crystals of the ALA salt have a mean diameter of 20 μm to 200 μm.

### Claim 2 (depends on 1)

Application system according to claim 1, characterised in that the polymer matrix is water-permeable.

### Claim 3 (depends on 1)

Application system according to claim 1, characterised in that a substantial amount of the crystals of the ALA salt have a mean diameter of 30 μm to 190 μm.

### Claim 4 (depends on 3)

Application system according to claim 3, characterised in that a substantial amount of the crystals of the ALA salt have a mean diameter of 90 μm to 160 μm.

### Claim 5 (depends on 1)

Application system according to claim 1, characterised in that the aminolaevulinic acid salt is present in a concentration of 1 to 50 wt. % relative to the polymer matrix.

### Claim 6 (depends on 1)

Application system according to claim 1, characterised in that it releases at least 30% of the ALA salt within 30 minutes.

### Claim 7

A dermal application system, which is a self-adhesive matrix system, consisting of aminolaevulinic acid (ALA) salt crystals suspended in a polymer matrix, wherein a substantial amount of the crystals of the ALA salt have a mean diameter of 20 μm to 200 μm.