# US 8,465,542 B2 · Steroid lipid-modified polyurethane as an implantable biomaterial, the preparation and uses thereof

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- Number: US 8,465,542 B2
- Document ID: US8465542B2
- Status: Granted
- Kind: B2
- Application number: 13/487,984
- Filed: 2012-06-04
- Published: 2012-12-13
- Granted: 2013-06-18
- Earliest claimed: 2003-07-08
- Assignees: The Children's Hospital of Philadelphia
- Applicants: Robert J. Levy; Ivan Alferiev; Stanley J. Stachelek
- Inventors: Robert J. Levy; Ivan Alferiev; Stanley J. Stachelek
- Web page: https://patentgrep.com/patent/US8465542B2

## CPC

- C08G 18/3876: {containing mercapto groups}
- A61L 27/18: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C08F 283/006: {on to polymers provided for in C08G18/00 (C08F283/004 takes precedence)}
- C08F 283/04: on to polycarbonamides, polyesteramides or polyimides {(C08F283/004 takes precedence)}
- C08G 18/83: Chemically modified polymers
- A61F 2/06: Blood vessels
- A61F 2/08: Muscles; Tendons; Ligaments
- A61F 2/24: Heart valves {; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body}
- A61F 2/82: Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents (stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07)
- C08G: MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- C08F: MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)

## Abstract

A modified polyurethane including a lipid substituent pendant from at least one urethane nitrogen and/or at least one carbon atom of the modified polyurethane, methods of preparing modified polyurethanes and the use thereof as an implantable biomaterial.

## Claims

### Claim 1

An implant produced by a process comprising the steps of:
providing a modified polyurethane comprising a lipid substituent pendant from at least one urethane nitrogen and/or at least one carbon atom of the modified polyurethane, wherein the lipid substituent is a thiol-modified cholesterol substituent or an amino-modified cholesterol substituent
forming an article from the modified polyurethane; and
contacting the article with cells to attach the cells to the lipid substituent and thereby attach the cells to the article to form the implant, provided that a portion of the cells remains attached to the implant when exposed to a fluid-induced shear stress.

### Claim 2 (depends on 1)

The implant of claim 1, wherein the implant is a member selected from the group consisting of an artificial heart; cardiac pacer leads; automatic implantable cardiodefibrillator leads; a prosthetic heart valve; a cardiopulmonary bypass membrane; a ventricular assist device; an annuloplasty ring; a dermal graft; a vascular graft; a vascular stent; cardiovascular stent; a structural stent; a catheter; a guide wire; a vascular shunt; a cardiovascular shunt; a dura mater graft; a cartilage graft; a cartilage implant; a pericardium graft; a ligament prosthesis; a tendon prosthesis; a urinary bladder prosthesis; a pledget; a suture; a permanently in-dwelling percutaneous device; an artificial joint; an artificial limb; a bionic construct; and a surgical patch.

### Claim 3 (depends on 1)

The implant of claim 1, wherein the cells are blood outgrowth endothelial cells.

### Claim 4 (depends on 1)

A method of treating a patient comprising providing the implant of claim 1, wherein the implant is seeded with blood outgrowth endothelial cells.