# US 8,465,539 B2 · Device viewable under an imaging beam

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- Number: US 8,465,539 B2
- Document ID: US8465539B2
- Status: Granted
- Kind: B2
- Application number: 13/047,226
- Filed: 2011-03-14
- Published: 2011-07-07
- Granted: 2013-06-18
- Earliest claimed: 2002-03-25
- Assignees: Kieran Murphy LLC
- Applicants: Kieran Murphy
- Inventors: Kieran Murphy
- Web page: https://patentgrep.com/patent/US8465539B2

## CPC

- A61L 31/18: Materials at least partially X-ray or laser opaque
- A61B 17/12022: {Occluding by internal devices, e.g. balloons or releasable wires (plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20)}
- A61B 17/12109: {in a blood vessel}
- A61B 17/12113: {within an aneurysm}
- A61B 17/12145: {having a pre-set deployed three-dimensional shape (methods of manufacturing A61B2017/00526)}
- A61B 17/3403: {Needle locating or guiding means}
- A61B 46/10: specially adapted for instruments{, e.g. microscopes}
- A61F 2/06: Blood vessels
- A61F 2/82: Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents (stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07)
- A61F 2/86: Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61L 31/10: Macromolecular materials
- A61L 31/16: Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)}
- A61B 10/0233: {Pointed or sharp biopsy instruments}
- A61B 17/3415: {for introducing tubes or catheters, e.g. gastrostomy tubes, drain catheters (A61B17/3417 takes precedence; body piercing catheter guide needles A61M25/06)}
- A61B 90/11: with guides for needles or instruments, e.g. arcuate slides or ball joints
- A61B 90/39: {Markers, e.g. radio-opaque or breast lesions markers}
- A61B 2017/1205: {Introduction devices}
- A61B 2090/374: {NMR or MRI}
- A61B 2090/376: {using X-rays, e.g. fluoroscopy}
- A61B 2090/3954: {magnetic, e.g. NMR or MRI}
- A61F 2210/0076: multilayered, e.g. laminated structures
- A61L 2300/416: Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
- A61L 2420/06: Coatings containing a mixture of two or more compounds
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)

## Abstract

The invention provides a stent made from a material operable to perform a stent's desired therapeutic functions, and also made from a material that has a radiopacity that substantially preserves the appearance of the stent when the stent is viewed under a CT imaging beam. Such a stent can allow for follow-up of the stent and the surrounding blood-vessel on CT.

## Claims

### Claim 1

A stent, comprising:
a material having structure to provide three-dimensional visualization of a surrounding tissue when said stent is inserted into said tissue and viewed under an imaging beam,
said stent having:
a single coating layer selected from a group consisting of: a hydrophilic polymer, a hydrophobic polymer, and a fatty acid polymer;
a density enhancing radiologic opacifier embedded into said single coating layer, said single coating layer and said embedded opacifier material together providing a first Hounsfield image density suitable for viewing under a first image modality used during device insertion into a patient, wherein said density enhancing radiologic opacifier material is configured to elute from said single coating layer so as to provide a second Hounsfield image density suitable for viewing under a second image modality used for subsequent visualization of surrounding tissue, and wherein the second Hounsfield image density is less than about 1200 Hounsfield Units; and
a restenosis inhibiting drug embedded into said single coating layer.

### Claim 2 (depends on 1)

The stent of claim 1, wherein residual radiographic density measurements of said stent provide a measure of said restenosis inhibiting drug still retained within said polymer.

### Claim 3 (depends on 1)

The stent of claim 1, wherein said stent is configured to elute said density enhancing radiologic opacifier material by bulk erosion.

### Claim 4 (depends on 1)

The stent of claim 1, wherein said stent is configured to elute said density enhancing radiologic opacifier material by surface erosion.

### Claim 5 (depends on 1)

The stent of claim 1, wherein said stent is configured to elute said density enhancing radiologic opacifier material by diffusion.

### Claim 6 (depends on 1)

The stent of claim 1, wherein said stent is configured to elute said density enhancing radiologic opacifier material by degradation.

### Claim 7 (depends on 1)

The stent of claim 1, wherein said imaging comprises CT.

### Claim 8 (depends on 1)

The stent of claim 1, wherein said imaging comprises MR.