# US 8,465,532 B2 · Fluorescent handpiece > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,465,532 B2 - Document ID: US8465532B2 - Status: Granted - Kind: B2 - Application number: 13/407,535 - Filed: 2012-02-28 - Published: 2012-08-30 - Granted: 2013-06-18 - Earliest claimed: 2008-01-16 - Applicants: Morgan Lars Ake Gustavsson - Inventors: Morgan Lars Ake Gustavsson - Web page: https://patentgrep.com/patent/US8465532B2 ## CPC - A61N 5/0613: {Apparatus adapted for a specific treatment} - A61N 5/0616: {Skin treatment other than tanning} - A61N 5/062: {Photodynamic therapy, i.e. excitation of an agent} - A61N 2005/005: {for cooling the radiator} - A61N 2005/063: {comprising light transmitting means, e.g. optical fibres} - A61N 2005/0644: {Handheld applicators} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract A handpiece can treat biological tissue using electromagnetic radiation, which can be substantially fluorescent light. The handpiece includes a source of electromagnetic radiation and a waveguide. The waveguide is adjacent the source, receives electromagnetic radiation from the source, and delivers the electromagnetic radiation to the biological tissue. The handpiece also includes a system for moving a fluorescent substance through the waveguide. The fluorescent substance includes a fluid base and a fluorescing agent and is capable of modulating at least one property of the electromagnetic radiation. A device is provided to remove a fluorescing agent from the fluorescing substance so that more of the same fluorescing agent can be added to clean fluid base. ## Claims ### Claim 1 A light-emitting, therapeutic system configured to treat biological tissue, comprising: a source of electromagnetic radiation; a waveguide positioned to receive electromagnetic radiation from the source, the waveguide comprising: first and second ends, and a wall extending therebetween, the wall configured to at least partially transmit the electromagnetic radiation therethrough, the wall defining a passage extending along a direction between said first and second ends; a fluorescent substance flowable within the passage, the fluorescent substance comprising a liquid base and a fluorescing agent; and an first port and an second port in fluid communication with the passage; an optical output element near one of the first and second ends of the waveguide; wherein the fluorescent substance is configured to absorb at least a portion of the electromagnetic radiation from the source through the wall and generate fluorescent light in response to the electromagnetic radiation, wherein the waveguide is configured to guide the fluorescent light emitted by the fluorescent substance towards the optical output element by internally reflecting at least a portion of the fluorescent light, and wherein the optical output element is configured to direct at least a portion of the fluorescent light towards biological tissue; a fluid conduit in fluid communication with the first and second ports and configured to carry the fluorescent substance between the waveguide's passage and a fluid moving system, the fluid moving system adapted to move the fluorescent substance from the first end to the second end through the passage and from the second end back to the first end through the fluid conduit; and a fluorescing agent removal device configured to be coupled to the fluid conduit and to remove the fluorescing agent from the fluorescent substance, the fluid conduit being configured to direct the fluorescent substance through the fluorescing agent removal device during a first mode of operation and to bypass the fluorescing agent removal device during a second mode of operation. ### Claim 2 (depends on 1) The therapeutic system of claim 1 wherein the source is selected from the group consisting of a flash lamp, a xenon flash lamp, a krypton flash lamp, a xenon-krypton flash lamp, an arc lamp, a laser, a diode, and an incoherent light source. ### Claim 3 (depends on 1) The therapeutic system of claim 1 further comprising a fluid input port in fluid communication with the fluid conduit and adapted to detachably connect to a reservoir cartridge, the reservoir cartridge configured to supply the fluorescent substance. ### Claim 4 (depends on 1) The therapeutic system of claim 1 wherein the fluorescent light delivered to the biological tissue is characterized by a pulse width between about 0.2 ms and about 500 s. ### Claim 5 (depends on 1) The therapeutic system of claim 1 wherein a spectrum characterizing the fluorescent light delivered to the biological tissue is matched to an absorption spectrum of at least one of whole blood, hemoglobin, reduced hemoglobin, or oxidized hemoglobin. ### Claim 6 (depends on 1) The therapeutic system of claim 1 wherein the fluorescent light delivered to the biological tissue is characterized by an energy density between about 0.1 J/cm2 and about 500 J/cm2. ### Claim 7 (depends on 1) The therapeutic system of claim 1 further comprising a controller for tuning one or more of a pulse width and fluence characterizing the fluorescent light delivered to the biological tissue. ### Claim 8 (depends on 1) The therapeutic system of claim 1 wherein a spectrum characterizing the fluorescent light delivered to the biological tissue is matched to an absorption spectrum of melanin in the biological tissue. ### Claim 9 (depends on 1) The therapeutic system of claim 1, further comprising a cooling fluid flow path at least part of which is configured to circulate cooling fluid between the waveguide and the source of electromagnetic radiation. ### Claim 10 (depends on 1) The therapeutic system of claim 1, wherein the fluorescing agent removal device comprises a filter, a deionization filter, or a particle filter. ### Claim 11 (depends on 1) The therapeutic system of claim 1, wherein the liquid base comprises one or more of: water, a solvent, an organic solvent, an alcohol, methanol, and ethanol. ### Claim 12 (depends on 1) The therapeutic system of claim 1, further comprising a dye source in fluid communication with the fluid conduit, the dye source configured to contain at least a portion of the fluorescent substance, wherein the dye source is selected from the group consisting of one or more of the following: a dye reservoir, a pellet, a tablet, a dye cartridge, a wet dye cartridge, a dry dye cartridge, a solution, a powder, a dye liquid, a receptacle, an ion exchange filter, an ion release filter, and a carbon filter. ### Claim 13 (depends on 1) The therapeutic system of claim 1, further comprising the fluid moving system, a base unit, an umbilicus connectable to the base unit, and a handpiece connectable to the umbilicus, wherein the fluid moving system is located within the handpiece. ### Claim 14 (depends on 1) The therapeutic system of claim 1, further comprising the fluid moving system, a base unit, an umbilicus connectable to the base unit, and a handpiece connectable to the umbilicus, wherein the fluid moving system is located within the base unit. ### Claim 15 (depends on 1) The therapeutic system of claim 1, wherein the fluid moving system comprises a fluid circulation system configured to circulate the fluorescent substance through the waveguide. ### Claim 16 (depends on 1) The therapeutic system of claim 1, further comprising a cooling system in fluid communication with the fluid conduit and configured to cool the fluorescent substance. ### Claim 17 A method of treating biological tissue, comprising: providing a light-emitting system adapted to treat biological tissue, said light-emitting system comprising: a waveguide positioned to receive electromagnetic energy from an electromagnetic energy source, the waveguide comprising: first and second ends, and a wall extending at least partially therebetween, the wall configured to transmit the electromagnetic radiation therethrough and defining a passage extending along a direction between said first and second ends; a fluorescent substance flowable within the passage, the fluorescent substance configured to absorb the electromagnetic radiation and generate fluorescent light in response to the electromagnetic radiation, the fluorescent substance comprising a liquid base and a fluorescing agent; and an input port and an output port in fluid communication with the passage; an optical output element near one of the first and second ends of the waveguide; a fluid conduit in fluid communication with the input and output ports; circulating the fluorescent substance from the first end to the second end through the passage and from the second end back to the first end through the fluid conduit; transmitting electromagnetic radiation through the wall of the waveguide to the fluorescent substance within the passage; guiding at least some of the fluorescent light emitted by the fluorescent substance in response to the electromagnetic radiation through the waveguide towards the optical output element; removing the fluorescing agent from the fluorescent substance by directing the fluorescent substance through a fluorescing agent removal device; and providing an additional quantity of the same fluorescing agent to the liquid base. ### Claim 18 (depends on 17) The method of claim 17, wherein the fluorescing agent removal device comprises a deionization filter. ### Claim 19 (depends on 17) The method of claim 17, wherein the providing an additional quantity of the fluorescing agent comprises adding a tablet, pellet, powder, or solution of dye to the liquid base. ### Claim 20 (depends on 17) The method of claim 17, wherein said providing comprises manually adding the fluorescing agent to the liquid base.