# US 8,465,453 B2 · Kits, apparatus and methods for magnetically coating medical devices with living cells

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 8,465,453 B2
- Document ID: US8465453B2
- Status: Granted
- Kind: B2
- Application number: 11/446,861
- Filed: 2006-06-05
- Published: 2006-12-21
- Granted: 2013-06-18
- Earliest claimed: 2003-12-03
- Assignees: Mayo Foundation for Medical Education and Research
- Applicants: Gurpreet S. Sandhu; Robert D. Simari; Nicole P. Sandhu; Rajiv Gulati
- Inventors: Gurpreet S. Sandhu; Robert D. Simari; Nicole P. Sandhu; Rajiv Gulati
- Web page: https://patentgrep.com/patent/US8465453B2

## CPC

- A61F 2/06: Blood vessels
- A61F 2/07: Stent-grafts
- A61F 2/958: Inflatable balloons for placing stents or stent-grafts
- A61L 27/28: Materials for coating prostheses
- A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)}
- A61L 27/56: Porous materials, {e.g. foams or sponges}
- A61L 27/58: Materials at least partially resorbable by the body
- A61N 2/06: using magnetic fields produced by permanent magnets (A61N2/12 takes precedence)
- A61F 2/04: Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts (A61F2/18, A61F2/20 take precedence; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95)
- A61F 2/24: Heart valves {; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body}
- A61F 2/82: Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents (stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07)
- A61F 2/90: characterised by a net-like or mesh-like structure
- A61F 2210/0004: bioabsorbable
- A61F 2210/009: magnetic
- A61N 1/05: for implantation or insertion into the body, e.g. heart electrode (A61N1/06 takes precedence)
- A61N 2001/0585: {Coronary sinus electrodes}
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)

## Abstract

Medical devices with surfaces on which viable biologic cells are magnetically attracted and retained are disclosed along with methods of magnetic coating. The medical devices can be located in a carrier liquid containing high concentrations of magnetic cells before or after implantation. The carrier liquid with magnetic cells may be contact with the medical device in vitro or in vivo. In either case, the carrier liquid may have a concentration of magnetic cells that is high enough to facilitate coating of the medical device within an acceptable period of time, e.g., several hours or less. Magnetization of medical devices before, during, and/or after implantation and apparatus for performing the same are disclosed. Degaussing of magnetic medical devices is also disclosed.

## Claims

### Claim 1

A kit for magnetically coating a medical device in vivo, the kit comprising:
an implantable medical device comprising a magnetic contact surface, wherein the implantable medical device is selected from the group consisting of a blood vessel stent, vascular graft, prosthesis for a biologic conduit, heart valve, left ventricular assist device, electronic lead, arterio-veinous fistula, and embolization coil, and wherein the implantable medical device exhibits a magnetic field strength in the range of 10 Gauss or less at that magnetic contact surface;
a catheter for creating a defined volume in a biologic conduit in vivo, wherein the catheter comprises:
a first end and a second end, wherein the second end is insertable into the biologic conduit;
a pair of seals capable of closing the biologic conduit when deployed within the conduit such that the defined volume in the biologic conduit is enclosed by the pair of seals;
a carrier liquid lumen extending from the first end of the catheter towards the second end of the catheter; and
an opening in the carrier liquid lumen between the seals, wherein carrier liquid in the carrier liquid lumen is capable of exiting the catheter through the opening.

### Claim 2 (depends on 1)

A kit according to claim 1, wherein each seal comprises an inflatable balloon, and further wherein the catheter comprises one or more inflation lumens extending from the first end of the catheter to the seals.

### Claim 3 (depends on 1)

A kit according to claim 1, wherein the biologic conduit comprises a blood vessel.

### Claim 4 (depends on 1)

A kit according to claim 1, further comprising means for associating a magnetic charge with a plurality of biologic cells to form the plurality of magnetic cells.

### Claim 5 (depends on 1)

A kit according to claim 1, wherein the catheter comprises a perfusion catheter that comprises a lumen passing fluid from an upstream side of the defined volume to a downstream side of the defined volume.

### Claim 6 (depends on 1)

A kit according to claim 1, the kit further comprising a magnetic field generator.

### Claim 7 (depends on 6)

A kit according to claim 6, wherein the magnetic field generator comprises a permanent magnet.

### Claim 8 (depends on 6)

A kit according to claim 6, wherein the magnetic field generator comprises an electronic coil and an electronic lead operably connected to the electronic coil.

### Claim 9 (depends on 6)

A kit according to claim 6, wherein the magnetic field generator comprises a medical grade catheter.

### Claim 10 (depends on 6)

A kit according to claim 6, wherein the magnetic field generator is located proximate a proximal end of an elongated body, wherein the elongated body comprises a lumen extending from the proximal end to a distal end of the elongated body, and wherein the implantable medical device is sized to pass through the lumen.

### Claim 11 (depends on 6)

A kit according to claim 6, wherein the implantable medical device comprises temporary magnetic material.

### Claim 12 (depends on 1)

A kit according to claim 1, wherein the kit further comprises a plurality of magnetic cells in a carrier liquid.

### Claim 13

A kit for magnetically coating a medical device in vivo, the kit comprising:
an implantable medical device comprising a magnetic contact surface, wherein the implantable medical device is selected from the group consisting of a blood vessel stent, vascular graft, prosthesis for a biologic conduit, heart valve, left ventricular assist device, electronic lead, arterio-veinous fistula, and embolization coil, and wherein the implantable medical device exhibits a magnetic field strength in the range of 10 Gauss or less at that magnetic contact surface; and
a catheter for use in a biologic conduit in vivo, wherein the catheter comprises:
a first end and a second end, wherein the second end is insertable into the biologic conduit;
a seal capable of closing the biologic conduit when deployed within the conduit;
a carrier liquid lumen extending from the first end of the catheter toward the second end of the catheter and extending through the seal; and
an opening in the carrier liquid lumen such that the opening is located between the second end of the catheter and the seal, wherein carrier liquid in the carrier liquid lumen is capable of exiting the catheter through the opening.

### Claim 14 (depends on 13)

A kit according to claim 13, wherein the seal comprises an inflatable balloon, and further wherein the catheter comprises an inflation lumen extending from the first end of the catheter to the seal.

### Claim 15 (depends on 13)

A kit according to claim 13, wherein the catheter comprises a perfusion catheter that comprises a lumen passing fluid from an upstream side of the defined volume to a downstream side of the defined volume.

### Claim 16 (depends on 13)

A kit according to claim 13, the kit further comprising a magnetic field generator.

### Claim 17 (depends on 16)

A kit according to claim 16, wherein the magnetic field generator comprises a permanent magnet.

### Claim 18 (depends on 16)

A kit according to claim 16, wherein the magnetic field generator comprises an electronic coil and an electronic lead operably connected to the electronic coil.

### Claim 19 (depends on 16)

A kit according to claim 16, wherein the magnetic field generator is located proximate a proximal end of an elongated body, wherein the elongated body comprises a lumen extending from the proximal end to a distal end of the elongated body, and wherein the implantable medical device is sized to pass through the lumen.

### Claim 20 (depends on 13)

A kit according to claim 13, wherein the kit further comprises a plurality of magnetic cells in a carrier liquid.

### Claim 21

A kit for magnetically coating a medical device in vivo, the kit comprising:
an implantable medical device comprising a magnetic contact surface, wherein the implantable medical device is selected from the group consisting of a blood vessel stent, vascular graft, prosthesis for a biologic conduit, heart valve, left ventricular assist device, electronic lead, arterio-veinous fistula, and embolization coil, and wherein the implantable medical device exhibits a magnetic field strength in the range of 10 Gauss or less at that magnetic contact surface; and
a catheter for creating a defined volume in a biologic conduit in vivo, wherein the catheter comprises:
a first end and a second end, wherein the second end is insertable into the biologic conduit;
a pair of seals capable of closing the biologic conduit when deployed within the conduit such that the defined volume in the biologic conduit is enclosed by the pair of seals;
a carrier liquid lumen extending from the first end of the catheter towards the second end of the catheter and extending through a seal of the pair of seals; and
an opening in the carrier liquid lumen located between the seals, wherein carrier liquid in the carrier liquid lumen is capable of exiting the catheter through the opening.

### Claim 22 (depends on 21)

A kit according to claim 21, wherein each seal comprises an inflatable balloon, and further wherein the catheter comprises an inflation lumen extending from the first end of the catheter to each seal.

### Claim 23 (depends on 21)

A kit according to claim 21, wherein the catheter comprises a perfusion catheter that comprises a lumen passing fluid from an upstream side of the defined volume to a downstream side of the defined volume.

### Claim 24 (depends on 21)

A kit according to claim 21, the kit further comprising a magnetic field generator.

### Claim 25 (depends on 24)

A kit according to claim 24, wherein the magnetic field generator comprises a permanent magnet.

### Claim 26 (depends on 24)

A kit according to claim 24, wherein the magnetic field generator comprises an electronic coil and an electronic lead operably connected to the electronic coil.

### Claim 27 (depends on 24)

A kit according to claim 24, wherein the magnetic field generator is located proximate a proximal end of an elongated body, wherein the elongated body comprises a lumen extending from the proximal end to a distal end of the elongated body, and wherein the implantable medical device is sized to pass through the lumen.

### Claim 28 (depends on 21)

A kit according to claim 21, wherein the kit further comprises a plurality of magnetic cells in a carrier liquid.