# US 8,465,408 B2 · Systems and methods for modulating the electrical activity of a brain using neuro-EEG synchronization therapy > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,465,408 B2 - Document ID: US8465408B2 - Status: Granted - Kind: B2 - Application number: 12/850,547 - Filed: 2010-08-04 - Published: 2011-02-10 - Granted: 2013-06-18 - Earliest claimed: 2009-08-06 - Assignees: Neosync, Inc. - Applicants: James William Phillips; Yi Jin - Inventors: James William Phillips; Yi Jin - Web page: https://patentgrep.com/patent/US8465408B2 ## CPC - A61N 2/006: {for magnetic stimulation of nerve tissue} - A61B 5/374: Detecting the frequency distribution of signals, e.g. detecting delta, theta, alpha, beta or gamma waves - A61B 5/4082: {Diagnosing or monitoring movement diseases, e.g. Parkinson, Huntington or Tourette} - A61B 5/6816: {Ear lobe} - A61B 5/6817: {Ear canal} - A61N 2/02: using magnetic fields produced by coils, including single turn loops or electromagnets (A61N2/12 takes precedence) - G16H 20/30: relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising - A61B 5/375: using biofeedback - A61B 5/4064: {Evaluating the brain (for intracranial pressure A61B5/031; for cerebral blood gases A61B5/14553; using EEG A61B5/369)} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA ## Abstract Described are methods, devices, and systems for a novel, inexpensive, easy to use therapy for treatment of coma, post-traumatic stress disorder, Parkinson's disease, cognitive performance, and/or amblyopia. Described are methods and devices to treat coma, post-traumatic stress disorder, Parkinson's disease, cognitive performance, and/or amblyopia that involves no medication. Methods and devices described herein use alternating magnetic fields to gently “tune” the brain and affect symptoms of coma, post-traumatic stress disorder, Parkinson's disease, cognitive performance, and/or amblyopia. ## Claims ### Claim 1 A method of treating Parkinson's disease, treating coma, treating post traumatic stress disorder (PTSD), treating amblyopia, and/or enhancing cognitive performance, in a subject, comprising: (a) adjusting a setting of a magnetic field such that the magnetic field is configured to do one or more of the following: move an intrinsic frequency of a specified EEG band of the subject toward a target intrinsic frequency of the specified EEG band using the magnetic field, move a Q-factor of the intrinsic frequency toward a target Q-factor of the intrinsic frequency using the magnetic field, move a coherence value of intrinsic frequencies among multiple sites in a brain of the subject within a specified EEG band toward a target coherence value using the magnetic field wherein if the coherence value is higher than the target coherence value, applying at least two asynchronous magnetic fields close to the head of the subject, and wherein if the coherence value is lower than the target coherence value, applying at least one synchronized magnetic field close to the head of the subject; and move an EEG phase between two sites in the brain of a subject of a specified EEG frequency toward a target EEG phase of the specified EEG frequency using the magnetic field wherein the magnetic field comprises one or more magnetic field generators that are of the same frequency and are in-phase with each other, of the same frequency and out of phase with each other, or a combination thereof; and (b) applying said magnetic field close to the head of the subject. ### Claim 2 A method of treating Parkinson's disease, treating coma, treating post traumatic stress disorder (PTSD), treating amblyopia, and/or enhancing cognitive performance in a subject, comprising moving at least one of: an intrinsic frequency of a brain of the subject within a specified EEG band toward a pre-selected intrinsic frequency within the same specified EEG band and a Q-factor of the intrinsic frequency toward a target Q-factor of the intrinsic frequency, by applying a magnetic field close to a head of the subject, wherein the magnetic field comprises at least one of(a) a single target frequency within the specified EEG band; (b) a plurality of frequencies within the specified EEG band; and (c) the intrinsic frequency of the brain of the subject within the specified EEG band. ### Claim 3 (depends on 1, 2) The method of claim 1 or 2, further comprising the step of measuring EEG data of the subject after the applying step. ### Claim 4 (depends on 1, 2) The method of claim 1 or 2, further comprising the steps of: adjusting frequency of said magnetic field based on the EEG data of the subject; and repeating the applying step with an adjusted frequency. ### Claim 5 (depends on 1, 2) The method of claim 1 or 2, wherein the applying of the magnetic field applies the magnetic field to a diffuse area of the brain of the subject. ### Claim 6 (depends on 1, 2) The method of claim 1 or 2, wherein the magnetic field is generated by movement of at least one permanent magnet. ### Claim 7 (depends on 6) The method of claim 6, wherein the strength of the at least one permanent magnet is from about 10 Gauss to about 4 Tesla. ### Claim 8 (depends on 7) The method of claim 7, wherein the distance between the at least one permanent magnet and the subject is from about 1/32 in to about 12 in. ### Claim 9 (depends on 1, 2) The method of claim 1 or 2, wherein the step of applying the magnetic field is for about 5 minutes to about two hours. ### Claim 10 (depends on 1, 2) The method of claim 1 or 2, further comprising repeating the applying step after an interval about 6 hours to about 14 days. ### Claim 11 (depends on 1, 2) The method of claim 1 or 2, further comprising: (a) locating a first electrode operable to detect electrical brain activity on the subject in at least one of an area of low electrical resistivity on the subject, and an area with substantially no electrical impulse interference on the subject; (b) locating a second electrode operable to detect a reference signal on the subject; and (c) determining the intrinsic frequency from the electrical brain activity detected by the first electrode and the reference signal detected by the second electrode. ### Claim 12 A device for use in treating Parkinson's disease, treating coma, treating post traumatic stress disorder (PTSD), treating amblyopia, and/or enhancing cognitive performance in a subject, comprising: a means for applying a magnetic field to a head of a subject; whereby the means for applying the magnetic field comprises: a first processor that controls the application of the magnetic field and wherein the first processor or a second processor moves at least one of: (a) an intrinsic frequency of a brain of the subject in a specified EEG band to a target intrinsic frequency within the specified EEG band using the magnetic field; (b) a Q-factor of an intrinsic frequency of the brain of the subject within a specified EEG band to a target Q-factor of the intrinsic frequency using the magnetic field; (c) a coherence value of intrinsic frequencies among multiple sites in the brain of the subject within a specified EEG band using the magnetic field wherein if the coherence value is higher than a pre-selected coherence value, applying at least two asynchronous magnetic fields close to the head of the subject, and wherein if the coherence value is lower than the pre-selected coherence value, applying at least one synchronized magnetic field close to the head of the subject; and (d) an EEG phase between two sites in the brain of the subject of a specified EEG frequency using the magnetic field wherein the magnetic field comprises a first magnetic field that is in-phase with a second magnetic field or a first magnetic field that is out of phase with a second magnetic field. ### Claim 13 (depends on 12) The device of claim 12, comprising at least one permanent magnet. ### Claim 14 (depends on 12) The device of claim 12, wherein the magnetic field is generated by movement of at least one permanent magnet. ### Claim 15 (depends on 14) The device of claim 14, wherein the movement of the at least one said magnet is at a frequency between about 0.5 Hz and about 100 Hz. ### Claim 16 (depends on 14) The device of claim 14, wherein said movement comprises at least one of rotational motion, linear motion, and swing motion. ### Claim 17 (depends on 14) The device of claim 14, wherein said movement generates an alternating magnetic field. ### Claim 18 (depends on 12) The device of claim 12, further comprising logic that controls the EEG frequency to be between about 0.5 Hz and about 100 Hz in increments of about 0.1 Hz. ### Claim 19 (depends on 12) The device of claim 12, further comprising logic that automatically changes the EEG frequency in response to EEG readings of the subject during treatment. ### Claim 20 (depends on 12) The device of claim 12, further comprising logic that calculates information from EEG data collected from the subject within a specified EEG band, wherein said information comprises at least one of items listed below: (a) the intrinsic frequency; (b) the Q-factor of the intrinsic frequency; (c) the coherence value of intrinsic frequencies; (d) the EEG phase; and (e) any combination thereof. ### Claim 21 (depends on 12) The device of claim 12, further comprising: (a) a first electrode operable to detect electrical brain activity; and (b) a second electrode operable to detect a reference signal; wherein the first electrode is adapted to be located on the subject in at least one of: an area of low electrical resistivity on the subject, and an area with substantially no electrical impulse interference on the subject, and wherein the second electrode is adapted to be located on the subject. ### Claim 22 A device for treating Parkinson's disease, treating coma, treating post traumatic stress disorder (PTSD), treating amblyopia, and/or enhancing cognitive performance in a subject, comprising: a magnetic field generator configured to apply a magnetic field close to a head of the subject, wherein the magnetic field generator comprises a first processor that controls the application of the magnetic field and wherein the first processor or a second processor moves an intrinsic frequency of a specified EEG band of the subject within the specified EEG band toward a target intrinsic frequency in the specified EEG band using the magnetic field, a Q-factor of the intrinsic frequency towards a target Q-factor of the intrinsic frequency using the magnetic field, a coherence value of intrinsic frequencies among multiple sites in a brain of the subject within a specified EEG band toward a target coherence value using the magnetic field wherein if the coherence value is higher than the target coherence value, applying at least two asynchronous magnetic fields close to the head of the subject, and wherein if the coherence value is lower than the target coherence value, applying at least one synchronized magnetic field close to the head of the subject; and an EEG phase between two sites in the brain of the subject of a specified EEG frequency toward a target EEG phase of the specified EEG frequency using the magnetic field wherein the magnetic field comprises one or more magnetic field generators that are of the same frequency and are in-phase with each other, of the same frequency and out of phase with each other, or a combination thereof. ### Claim 23 (depends on 22) The device of claim 22, wherein the magnetic field comprises at least one of(a) a single target frequency within the specified EEG band; (b) a plurality of frequencies within the specified EEG band; and (c) the intrinsic frequency of the brain of the subject within the specified EEG band.