# US 8,464,711 B2 · Methods for treating headaches

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- Number: US 8,464,711 B2
- Document ID: US8464711B2
- Status: Granted
- Kind: B2
- Application number: 12/917,141
- Filed: 2010-11-01
- Published: 2011-02-24
- Granted: 2013-06-18
- Earliest claimed: 1999-07-12
- Assignees: Capnia, Inc.
- Applicants: Ned S. Rasor; Julia S. Rasor
- Inventors: Ned S. Rasor; Julia S. Rasor
- Web page: https://patentgrep.com/patent/US8464711B2

## CPC

- A61M 31/00: Devices for introducing or retaining media, e.g. remedies, in cavities of the body (A61M25/00 takes precedence {; introducing or retaining ophthalmic products into the ocular cavities A61F9/0008})
- A61H 33/14: Devices for gas baths with ozone, hydrogen, or the like (production of ozone or hydrogen C01B, C25B1/02)
- A61M 11/04: operated by the vapour pressure of the liquid to be sprayed or atomised {(air-humidification, e.g. "room humidifiers" F24F6/00)}
- A61M 11/047: {by exothermic chemical reaction}
- A61M 15/0041: {with movable piercing or cutting means}
- A61M 15/009: {using medicine packages with incorporated spraying means, e.g. aerosol cans (pocket atomiser of the injector type A61M11/08)}
- A61M 37/00: Other apparatus for introducing media into the body (for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30); Percutany, i.e. introducing medicines into the body by diffusion through the skin (salt baths A61H33/04)
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 11/00: Drugs for disorders of the respiratory system
- A61P 11/02: Nasal agents, e.g. decongestants
- A61P 11/06: Antiasthmatics
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/02: for peripheral neuropathies
- A61P 25/06: Antimigraine agents
- A61P 25/08: Antiepileptics; Anticonvulsants
- A61P 25/16: Anti-Parkinson drugs
- A61P 27/02: Ophthalmic agents
- A61P 27/14: Decongestants or antiallergics
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 37/08: Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14)
- A61H 2033/145: {with CO2}
- A61M 15/0065: {Inhalators with dosage or measuring devices (A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52)}
- A61M 2202/0007: introduced into the body
- A61M 2202/0225: Carbon oxides, e.g. Carbon dioxide
- A61M 2202/064: Powder
- A61M 2205/8225: using incorporated gas cartridges for the driving gas
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- A61H: PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY (electrotherapy, magnetotherapy, radiation therapy or ultrasound therapy A61N)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Apparatus, methods, and kits for treating symptoms associated with common ailments, such as headaches, rhinitis, asthma, epilepsy, nervous disorders and the like, are provided. The apparatus comprises dispensers for carbon dioxide and other therapeutic gases. The methods comprise delivering small volumes of these gases to patients in a manner where the gas infuses into a body region in order to bathe the mucous membranes therein. It has been found that even very short exposure of patients to small volumes and high concentrations of such gases can provide significant relief from symptoms.

## Claims

### Claim 1

A method for treating a headache in a patient in need of such treatment, said method comprising:
releasing from a hand-held dispenser a therapeutic, non-inhaled, dosage of a gas comprising at least 50% carbon dioxide by volume, wherein the therapeutic dosage of the gas is accomplished at a repeatable flow rate from 1 cc/sec to 20 cc/sec; and
instructing the patient to substantially refrain from inhaling while the gas is being released.

### Claim 2 (depends on 1)

The method of claim 1, wherein the duration is from 1-100 seconds per nostril.

### Claim 3 (depends on 1)

The method of claim 1, wherein the dose is repeated from 1 to 10 times.

### Claim 4 (depends on 1)

The method of claim 1, wherein the headache is a migraine headache.

### Claim 5 (depends on 1)

The method of claim 1, wherein the hand held dispenser is a two-piece dispenser.

### Claim 6 (depends on 1)

The method of claim 1, wherein the hand held dispenser is a one-piece dispenser.

### Claim 7 (depends on 1)

The method of claim 1, wherein the headache is a tension-type headache.

### Claim 8 (depends on 1)

The method of claim 1, wherein the flow rate is selected by the patient.

### Claim 9 (depends on 1)

The method of claim 1, wherein the flow rate is from 4 cc/sec to 5 cc/sec.

### Claim 10 (depends on 1)

The method of claim 1, wherein the flow rate is from 1 cc/sec to 5 cc/sec.

### Claim 11 (depends on 1)

The method of claim 1, wherein the flow rate is from 2 cc/sec to 10 cc/sec.

### Claim 12 (depends on 1)

The method of claim 1, wherein the flow rate is 10 cc/sec.

### Claim 13 (depends on 1)

The method of claim 1, wherein the gas comprises at least 70% carbon dioxide.

### Claim 14 (depends on 1)

The method of claim 1, wherein the gas comprises at least 95% carbon dioxide.

### Claim 15 (depends on 1)

The method of claim 1, wherein the gas comprises substantially pure carbon dioxide.

### Claim 16 (depends on 2)

The method of claim 2, wherein the duration is from 2-30 seconds.

### Claim 17 (depends on 16)

The method of claim 16, wherein the duration is from 1-20 seconds.