Methods of modifying insulin signaling using biliverdin reductase
AssigneeUniversity of Rochester
InventorMahin D. Maines
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Abstract
The present invention relates to a method of modulating insulin signaling in a cell. This method involves modifying the nuclear or cellular concentration of biliverdin reductase, or fragments or variants thereof, in a cell, whereby a change in nuclear or cellular concentration of biliverdin reductase, or fragments or variants thereof, modulates insulin signaling in the cell via biliverdin reductase interaction with one or both of insulin receptor kinase domain and insulin receptor substrate. Also disclosed are methods of treating a condition associated with insulin signaling and treating a patient for a condition associated with insulin-mediated glucose uptake.
Claims4
A method of treating a condition associated with insulin-mediated cellular glucose uptake, said method comprising:
- selecting a mammalian subject having a condition associated with insulin-mediated cellular glucose uptake and
- administering to the subject a C-terminal peptide fragment of biliverdin reductase that comprises an amino acid sequence of YCCS and achieves an increase in insulin-mediated cellular glucose uptake, thereby treating the condition associated with insulin-mediated cellular glucose uptake.
Dependencies are inferred from the claim text.