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US 8,454,945 B2Granted
Topical formulations having enhanced bioavailability
AssigneeBerg Pharma LLC
InventorsJohn Patrick McCook, Indushekhar Persaud, Niven Rajin Narain
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Abstract
The present disclosure provides compositions suitable for delivering lipophilic bioactive agents. The compositions may be utilized to treat numerous diseases and conditions that would benefit from the application of a lipophilic bioactive agent.
Claims33
A composition comprising:
- a liposomal concentrate comprising a phospholipid selected from the group consisting of lecithin, lysolecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylglycerol, phosphatidic acid, phosphatidylserine, lysophosphatidylcholine, lysophosphatidylethanolamine, lysophosphatidylglycerol, lysophosphatidic acid, lysophosphatidylserine, PEG-phosphatidylethanolamine, PVP-phosphatidylethanolamine, and combinations thereof;
- Coenzyme Q10;
- and at least one solubilizer;
- in combination with at least one pharmaceutically acceptable carrier possessing at least one permeation enhancer, wherein the at least one permeation enhancer comprises ethoxydiglycol in an amount from about 2% by weight to about 8% by weight of the composition, and
- wherein the phospholipid is present in the composition in an amount of from about 2% by weight to about 20% by weight of the composition and the Coenzyme Q10 is present in an amount of from about 1.25% to about 5% by weight of the composition;
- and
- wherein the composition is capable of providing a penetration of the Coenzyme Q10 to the epidermis of at least about 12%.
4 more elements
Dependencies are inferred from the claim text.