Amine derivative compounds for treating ophthalmic diseases and disorders

A method for treating an ophthalmic disease or disorder resulting at least in part from lipofuscin pigment accumulation in a subject, comprising administering to the subject a compound of Formula (A) or tautomer, stereoisomer, geometric isomer or a pharmaceutically acceptable salt, or N-oxide thereof:

• wherein,
• Z is —C(R9)(R10)—C(R1)(R2)—,
• G is —C(R41)2—C(R41)2—R40,
• R40 is —C(R16)(R17)(R18;
• each R41 is hydrogen;
• R1 and R2 are each independently selected from hydrogen, halogen, C1-C5 unsubstituted alkyl, or hydroxy;
• or R1 and R2 together form an oxo;
• R3 and R4 are hydrogen;
• R9 and R10 are each independently selected from hydrogen, halogen, C1-C5 unsubstituted alkyl, or hydroxyl or R9 and R10 form an oxo;
• R11 and R12 are hydrogen;
• R16 and R17 are each independently selected from hydrogen, phenyl, benzyl, or C1-C5 alkyl optionally substituted with —ORa or —C(O)NRa2 wherein Ra is hydrogen or methyl;
• or R16 and R17, together with the carbon to which they are attached form a carbocyclyl or heterocycle;
• R18 is selected from hydrogen, C1-C5 unsubstituted alkyl, methoxy, or hydroxy;
• R33 is C1-C5 alkyl;
• and n is 0, or 1.