Fusion proteins of collagen-binding domain and parathyroid hormone
AssigneesBoard of Trustees of the University of Arkansas, Ochsner Clinic Foundation, National University Corporation Kagawa University
InventorsJoshua Sakon, Robert C. Gensure, Osamu Matsushita
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Abstract
Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.
Claims7
A composition comprising:
- a collagen-binding polypeptide segment covalently linked to a PTH/PTHrP receptor agonist;
- wherein the collagen-binding polypeptide segment is a bacterial collagen binding polypeptide segment, wherein the PTH/PTHrP receptor agonist comprises residues 1-14 of SEQ ID NO:
- 1, and wherein the collagen-binding polypeptide segment comprises residues 38-158 of SEQ ID NO:
- 1, or is at least 90% identical to residues 38-158 of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.