Conjugation reactions
AssigneeBiocompatibles UK Limited
InventorsAndrew Lennard Lewis, Simon William Leppard
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Abstract
An initiator for the terminal group of the polymer product of an atom or group radical transfer polymerisation has an activated carboxyl or an amine group which is reacted with an amine or carboxyl (respectively) group containing biologically active compound. The initiator is preferably 4-(3-(2-bromo, 2-methyl-propionate)phenyl)-propionic acid N-hydroxysuccinimide ester or 2-bromo, 2-methyl-propionic acid N-hydroxysuccinimide ester. The monomers preferably comprise a zwitterionic monomer such as 2-methacryloxyethyl-2′-trimethyl ammoniumethyl phosphate inner salt.
Claims4
A polymerisation process in which ethylenically unsaturated monomers are polymerised by atom or group radical transfer polymerisation in the presence of an initiator selected from 4-(3-(2-bromo, 2-methyl-propionate)phenyl)-propionic acid N-hydroxysuccinimide ester and 2-bromo, 2-methyl-propionic acid N-hydroxysuccinimide ester to form a polymer product having an N-hydroxysuccinimide ester terminal group.
Dependencies are inferred from the claim text.