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US 8,445,218 B2Granted
Device and methods for the immunological identification of cerebrospinal fluid
AssigneeAffinimark Technologies, Inc.,
InventorVincent Pieribone
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Abstract
The present disclosure relates to detection of the presence or absence of cerebrospinal fluid (CSF) in a sample by the detection of one or more antigens that are enriched in CSF compared to their levels in other bodily fluids. The devices and methods are suitable for the detection of the presence or absence of cerebrospinal fluid in samples of mixed bodily fluids from a wide variety of human populations crossing ethnicity, age, gender, health status and genetic variability.
Claims14
A device for detection of the presence or absence of cerebrospinal fluid in a sample, comprising
- a sample application region,
- a sample labeling region comprising a first antibody to a CSF-enriched protein, wherein the first antibody is conjugated to a mobile particle;
- a sample detection region comprising a second antibody to the CSF-enriched protein, wherein the second antibody is fixed to the sample detection region,
- wherein the presence of a detectable band in the sample detection region indicates the presence of cerebrospinal fluid in the sample, wherein the CSF-enriched protein is selected from the group consisting of SEQ ID NO:2, SEQ ID NO:
- 5, SEQ ID NO:
- 7 and SEQ ID NO:
- 8.
4 more elements
Dependencies are inferred from the claim text.