Antioxidant inflammation modulators: oleanolic acid derivatives with amino acid and other modifications at C-17

A pharmaceutical composition comprising a compound of the formula:

• wherein:
• Y is hydroxy or NR1R2, wherein:
• R1 and R2 are independently:
• hydrogen or hydroxy;
• or
• alkyl(C≦12), alkenyl(C≦12), alkynyl(C≦12), aryl(C≦12), aralkyl(C≦12), heteroaryl(C≦12), heteroaralkyl(C≦12), acyl(C≦12), alkoxy(C≦12), alkenyloxy(C≦12), alkynyl-oxy(C≦12), aryloxy(C≦12), aralkoxy(C≦12), heteroaryl-oxy(C≦12), heteroaralkoxy(C≦12), thioacyl(C≦12), alkylsulfonyl(C≦12), alkenylsulfonyl(C≦12), alkynyl-sulfonyl(C≦12), arylsulfonyl(C≦12), aralkyl-sulfonyl(C≦12), heteroarylsulfonyl(C≦12), or hetero-aralkylsulfonyl(C≦12), or a substituted version of any of these groups;
• or a pharmaceutically acceptable salt, tautomer, or optical isomer thereof;
• and
• a pharmaceutically acceptable carrier.