Methods of treating hypertriglyceridemia
AssigneeAmarin Pharmaceuticals Ireland Limited
InventorsMehar Manku, Ian Osterloh, Pierre Wicker, Rene Breackman, Paresh Soni
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Abstract
In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.
Claims14
A method of reducing triglycerides in a subject having a fasting baseline triglyceride level of 500 mg/dl to about 1500 mg/dl comprising, administering orally to the subject about 4 g per day of a pharmaceutical composition comprising at least about 90% ethyl eicosapentaenoate, by weight of total fatty acids present, and not more than about 3% docosahexaenoic acid or its esters, by weight of total fatty acids present, for a period of 12 weeks to effect a reduction in triglycerides in the subject.
A method of reducing triglycerides in a subject having a fasting baseline triglyceride level of 500 mg/dl to about 1500 mg/dl comprising, administering orally to the subject about 4 g per day of a pharmaceutical composition comprising at least about 90% ethyl eicosapentaenoate, by weight of total fatty acids present, and not more than about 3% docosahexaenoic acid or its esters, by weight of total fatty acids present, for a period of 12 weeks to effect a reduction in triglycerides in the subject compared to placebo control.
Dependencies are inferred from the claim text.