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US 8,436,148 B2Granted
Antibodies against interleukin-18 binding protein, their preparation and use
AssigneeYeda Research and Development Co. Ltd.
InventorsCharles Dinarello, Menachem Rubinstein, Soo Hyun Kim, Daniela Novick
Life of this patent
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Abstract
Interleukin-18 binding proteins which are capable of binding IL-18 and/or modulating and/or blocking IL-18 activity are provided. Methods for their isolation and recombinant production, DNAs encoding them, DNA vectors expressing them, vectors useful for their expression in humans and other mammals, antibodies against them are also provided.
Claims3
An isolated monoclonal antibody to IL-18BP, wherein the IL-18BP is selected from the group consisting of:
- (a) a polypeptide consisting of amino acids 29-192 of SEQ ID NO:2 and
- (b) a polypeptide consisting of amino acids 29-197 of SEQ ID NO:
- 6.
Dependencies are inferred from the claim text.