Cerebrospinal fluid purification system
AssigneeNeurofluidics, Inc.
InventorsShivanand Lad, William C. Mobley, Karoly Nikolich, Thomas Saul
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Abstract
The present invention provides methods and systems for conditioning cerebrospinal fluid (CSF) by removing target compounds from CSF. A multilumen flow path allows exchange of a majority volume portion of CSF in the CSF space. The removal and/or delivery of specific compounds can be tailored to the pathology of the specific disease. The removal is targeted and specific, for example, through the use of specific size-exclusion thresholds, antibodies against specific toxins, and other chromatographic techniques, as well as delivery and/or removal of targeted therapeutic agents.
Claims12
A method for ameliorating a symptom of cerebral vasospasm in a patient, said method comprising:
- selecting a patient having the symptom of cerebral vasospasm;
- removing cerebrospinal fluid from a first location in a lumbar cerebrospinal fluid space of the patient;
- removing at least one of erythrocytes, hemoglobin, oxyhemoglobin and endothelin from the removed cerebrospinal fluid, thereby conditioning the cerebrospinal fluid at a flow rate;
- and
- returning the conditioned cerebrospinal fluid to the patient at a second location in a cervical cerebrospinal fluid space or ventricle of the patient, wherein the cerebrospinal fluid is returned to the patient at substantially the same flow rate at which it is removed;
- wherein the removing and returning steps are performed concurrently using a catheter having a first lumen with a first proximal port at the first location and a second lumen having a second distal port at the second location during at least a portion of a conditioning treatment.
Dependencies are inferred from the claim text.