A heat-treated tobacco composition comprising a tobacco material, a buffering agent that buffers within a pH range of about 6 to about 10, and an additive selected from the group consisting of lysine, glycine, histidine, alanine, methionine, glutamic acid, aspartic acid, proline, phenylalanine, valine, arginine, cysteine, asparaginase, and combinations thereof, wherein the heat-treated tobacco composition has an acrylamide content of less than about 1500 ppb, wherein the heat-treated tobacco composition is incorporated into a smokeless tobacco composition.