Compositions and methods for treating aids or cancer by inhibiting the secretion of microparticles
AssigneeMorehouse School of Medicine
InventorsVincent Craig Bond, Michael Powell, Ming Bo Huang, Syed Ali, Andrea D. Raymond, Martin Neville Shelton, Francois Jean Villinger
Life of this patent
Estimating the term…
Abstract
Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides.
Claims23
A peptide for inhibiting the release of microparticles in a cell, said peptide comprising the amino acid sequence of SEQ ID NO:
- 2 (VGFPVAAVGFPV).
A pharmaceutical composition comprising:
- (1) a peptide comprising the amino acid sequence of SEQ ID NO:
- 2 or an expression vector encoding such a peptide;
- and
- (2) a pharmaceutically acceptable carrier.
A method for treating AIDS, comprising:
- administering to a subject in need of such treatment an effective amount of a peptide comprising the amino acid sequence of SEQ ID NO:
- 2.
A method for treating a tumor, comprising:
- administering to a subject in need of such treatment an effective amount of a peptide comprising the amino acid sequence of SEQ ID NO:
- 2.
A method for treating AIDS, comprising:
- administering to a subject in need of such treatment an effective amount of an expression vector comprising a polynucleotide encoding a peptide comprising the amino acid sequence of SEQ ID NO:
- 2 (VGFPVAAVGFPV), wherein said expression vector is capable of expressing said peptide in vivo.
Dependencies are inferred from the claim text.