Norovirus vaccine formulations
AssigneeTakeda Vaccines (Montana), Inc.
InventorsCharles Richardson, Thomas S. Vedvick, Thomas R. Foubert, William T. Tino
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Abstract
The present invention relates to antigenic and vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to a process for the production of both monovalent and multivalent VLPs, the VLPs comprising capsid proteins from one or more Norovirus genogroups.
Claims32
A composition comprising at least one Norovirus antigen and at least one adjuvant, wherein the adjuvant is a toll-like receptor (TLR) agonist, and wherein the composition is formulated as a liquid.
A composition comprising at least one Norovirus antigen and an aluminum salt, wherein the composition is formulated as a liquid.
A method of inducing an immune response to Norovirus in a mammal comprising administering to the mammal a composition comprising a Norovirus antigen and at least one adjuvant, wherein said adjuvant is not a bacterial exotoxin, and wherein the Norovirus antigen is from a genogroup I or genogroup II Norovirus.
Dependencies are inferred from the claim text.