Signal processing algorithms for impedance biosensor
AssigneeSharp Laboratories of America, Inc.
InventorDean Messing
Life of this patent
Estimating the term…
Abstract
A method for determining impedance includes receiving a time varying voltage signal from a biosensor and receiving a time varying current signal from the biosensor. The time varying voltage signal and the time varying current signal are transformed to a domain that represents complex values. The impedance representative of the biosensor based upon the transformed time varying voltage signal and the time varying current signal is calculated.
Claims21
A method for determining impedance comprising:
- (a) receiving a time varying voltage signal associated with a biosensor;
- (b) receiving a time varying current signal associated with said biosensor;
- (c) transforming said time varying voltage signal and said time varying current signal to a domain that represents complex values;
- (d) calculating a decay rate based upon said transformed time varying voltage signal and said time varying current signal.
A method for determining impedance comprising:
- (a) receiving a time varying voltage signal associated with a biosensor;
- (b) receiving a time varying current signal associated with said biosensor;
- (c) transforming said time varying voltage signal and said time varying current signal to a domain that represents complex values;
- (d) calculating an impedance representative of said biosensor based upon said transformed time varying voltage signal and said time varying current signal;
- (e) wherein a discrete-time Fourier transform of said time varying voltage signal is determined;
- (f) wherein said transform is evaluated at substantially the same frequency as a driving signal of said biosensor;
- (g) wherein a correction is applied to said time varying voltage signal in such a manner to reduce the effect of a finite time aperture.
A method for determining impedance comprising:
- (a) receiving a time varying voltage signal associated with a biosensor;
- (b) receiving a time varying current signal associated with said biosensor;
- (c) transforming said time varying voltage signal and said time varying current signal to a domain that represents complex values;
- (d) calculating an impedance representative of said biosensor based upon said transformed time varying voltage signal and said time varying current signal;
- (e) wherein a discrete-time Fourier transform of said time varying current signal is determined;
- (f) wherein said transform is evaluated at substantially the same frequency as a driving signal of said biosensor;
- (g) wherein a correction is applied to said time varying current signal in such a manner to reduce the effect of a finite time aperture.
A method for determining impedance comprising:
- (a) receiving a time varying voltage signal associated with a biosensor;
- (b) receiving a time varying current signal associated with said biosensor;
- (c) transforming said time varying voltage signal and said time varying current signal to a domain that represents complex values;
- (d) calculating an impedance representative of said biosensor based upon said transformed time varying voltage signal and said time varying current signal;
- (e) calculating a decay rate based upon said impedance.
A method for determining impedance comprising:
- (a) receiving a time varying voltage signal associated with a biosensor;
- (b) receiving a time varying current signal associated with said biosensor;
- (c) estimating multiple sets of amplitude and decay rate pairs from said time varying voltage signal and said time varying current signal response of said biosensor;
- (d) distinguishing between binding processes at said biosensor based upon at least two of said amplitude and decay rate pairs.
A method for determining impedance comprising:
- (a) receiving a time varying voltage signal associated with a biosensor;
- (b) receiving a time varying current signal associated with said biosensor;
- (c) distinguishing multiple binding rates based upon said time varying voltage signal and said time varying current signal response of said biosensor.
Dependencies are inferred from the claim text.