Multi-component medicine evaluation method

A computer implemented method for evaluation of a multi-component medicine comprising judging the degree of difference of the multi-component medicine to be evaluated from a group of multi-component medicines selected as a reference group by using a Mahalanobis distance obtained by a process comprising;

• providing a programmed processor that performs the following:
• (1) obtaining chromatographic high performance liquid chromatography fingerprint data of three-dimensional high performance liquid chromatography of the multi-component medicine to be evaluated,
• (2) combining the chromatographic high performance liquid chromatography fingerprint data obtained in (1) with chromatographic high performance liquid chromatography fingerprint data of three-dimensional high performance liquid chromatography of other multi-component medicines of the same kind forming a reference group,
• (3) allocating variable axes to the number of multi-component medicine and either the elution time or detection wavelength of the chromatographic high performance liquid chromatography fingerprint data of (2) above and regarding a signal strength as a characteristic amount,
• (4) obtaining a unit space from the characteristic amount of (3),
• (5) obtaining the Mahalanobis distance of all multi-component medicines for each detection wavelength or elution time from the unit space obtained in (4),
• (6) allocating variable axes to the number of the multi-component medicine and either the elution time or detection wavelength to which the variable axes are not allocated in (3) and regarding the Mahalanobis distance obtained in (5) as a characteristic amount,
• (7) obtaining a second unit space from the characteristic amount of (6), and
• (8) obtaining the Mahalanobis distance of the multi-component medicine to be evaluated from the second unit space obtained in (7).

A system for judging the degree of difference of one multi-component medicine from two or more multi-component medicines in an integrated manner, the system performing at least the following (A) to (D),

• (A) storing chromatographic high performance liquid chromatography fingerprint data acquired from three-dimensional high performance liquid chromatography of two or more multi-component medicines forming a reference group,
• (B) inputting the chromatographic high performance liquid chromatography fingerprint data acquired from three-dimensional high performance liquid chromatography of the multi-component medicine being evaluated and combining that data with the chromatographic high performance liquid chromatography fingerprint data stored in (A) above to produce one data group,
• (C) allocating variable axes to the number of multi-component medicines and the elution time or detection wavelength of the group of data of (B) above to obtain the unit space using a signal strength as a characteristic, and
• (D) obtaining a Mahalanobis distance from the above unit space of the multi-component medicine to be evaluated.

A computer readable storage media that when executed by a computer program carries out the following:

• (A) storing chromatographic high performance liquid chromatography fingerprint data acquired from three-dimensional high performance liquid chromatography of two or more multi-component medicines forming a reference group,
• (B) inputting the chromatographic high performance liquid chromatography fingerprint data acquired from three-dimensional high performance liquid chromatography of the multi-component medicine being evaluated and combining that data with the chromatographic high performance liquid chromatography fingerprint data stored in (A) above to produce one data group,
• (C) allocating variable axes to the number of multi-component medicines and the elution time or detection wavelength of the group of data of (B) above to obtain the unit space using a signal strength as a characteristic amount, and
• (D) obtaining a Mahalanobis distance from the above unit space of the multi-component medicine to be evaluated.