Susceptibility-matched multi-well sample holders for high-throughput screening by magnetic analysis
AssigneeThe Government of the United States of America as represented by the Secretary of the Department of Health and Human Services
InventorKenneth W. Fishbein
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Abstract
A method of performing high throughput magnetic sensing of one or more samples. The method comprises selecting a first sample having a first bulk magnetic susceptibility, selecting an assay plate having a second bulk magnetic susceptibility matched to the first bulk magnetic susceptibility, the assay plate including multiple wells, introducing the first sample into a plurality of the wells, and performing magnetic sensing on the plurality of wells containing the first sample. Assay plates, caps, kits, and other devices and methods relating to high throughput magnetic sensing are also disclosed.
Claims27
A method of performing high throughput magnetic resonance analysis of one or more samples, the method comprising:
- selecting a first sample having a first bulk magnetic susceptibility;
- selecting an assay plate constructed from a material having a second bulk magnetic susceptibility, the assay plate including a plurality of wells;
- introducing the first sample into at least one of the plurality of wells;
- inserting a cap into at least one or more of the plurality of the wells, wherein each cap is constructed from a material having a third bulk magnetic susceptibility wherein the cap includes one or more vent holes configured to permit air and/or the sample to be evacuated from the at least one of the plurality of wells;
- and
- performing magnetic resonance analysis on the plurality of wells of the assay plate, wherein performing magnetic resonance analysis individually on the wells of the assay plate comprises using the PRESS sequence to acquire NMR spectra from one well at a time.
Dependencies are inferred from the claim text.