# US 8,426,383 B2 · Anti-aging composition for external use comprising low and high molecular weight hyaluronic acids and the polysaccharides extracted from root bark of Ulmus davidiana

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- Number: US 8,426,383 B2
- Document ID: US8426383B2
- Status: Granted
- Kind: B2
- Application number: 12/922,353
- Filed: 2009-03-12
- Published: 2011-01-06
- Granted: 2013-04-23
- Earliest claimed: 2008-03-13
- Assignees: Bioland
- Applicants: Ki Ho Kim; Ki Soo Kim; Young Heui Kim; Jin Guk Kim; Kyoung Tae Kim; Chang Sung Han; Kang II Ko
- Inventors: Ki Ho Kim; Ki Soo Kim; Young Heui Kim; Jin Guk Kim; Kyoung Tae Kim; Chang Sung Han; Kang II Ko
- Web page: https://patentgrep.com/patent/US8426383B2

## CPC

- A61K 8/735: {Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof}
- A61K 8/9789: Magnoliopsida [dicotyledons]
- A61K 36/185: Magnoliopsida (dicotyledons)
- A61P 17/00: Drugs for dermatological disorders
- A61P 17/16: Emollients or protectives, e.g. against radiation
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61Q 19/08: Anti-ageing preparations
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Disclosed is an anti-aging composition for external use on skin, which includes low-molecular weight hyaluronic acids, high-molecular weight hyaluronic acids and polysaccharides extracted from root bark of Ulmus davidiana, as active ingredients. The composition including the low-molecular weight hyaluronic acids, high-molecular weight hyaluronic acids and polysaccharides extracted from root bark of Ulmus davidiana, in a predetermined ratio, shows significantly improved skin-moisturizing, skin elasticity-enhancing and inflammation-alleviating effects, as compared to a composition using one of the above ingredients alone. Therefore, the composition may be widely used as a pharmaceutical or cosmetic anti-aging composition.

## Claims

### Claim 1

A composition for external use on skin, which comprises 15 to 70 wt. % of low-molecular weight hyaluronic acids, 15 to 60 wt % of high-molecular weight hyaluronic acids, and 15 to 60 wt % of polysaccharides extracted from root bark of Ulmus davidiana, as active ingredients, wherein the weight is based on the total weight of the composition, wherein the high-molecular weight hyaluronic acids have an average molecular weight of 500,000 Da to 3,000,000 Da, and the low-molecular weight hyaluronic acids have an average molecular weight of 500 Da to 50,00 Da, and wherein skin treated with the composition demonstrates an increased skin elasticity-enhancing effect as compared to skin treated with a composition including only one of low-molecular weight hyaluronic acids, high-molecular weight hyaluronic acids, or polysaccharides extracted from root bark of Ulmus davidiana.

### Claim 2 (depends on 1)

The composition for external use on skin according to claim 1, which has moisturizing, skin elasticity-enhancing and anti-inflammatory effects.

### Claim 3 (depends on 1)

The composition for external use on skin according to claim 1, which is provided in any one formulation selected from the group consisting of cream, gel, patch, spray agent, ointment, plaster, lotion, liniment, paste and cataplasm.

### Claim 4 (depends on 1)

The composition for external use on skin according to claim 1, which is provided in any one formulation selected from the group consisting of skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisturizing lotion, nourishing lotion, massage cream, nourishing cream, moisturizing cream, hand cream, foundation, essence, nourishing essence, pack, soap, cleansing foam, cleansing lotion, cleansing cream, body lotion and body cleanser.