Derivatives of 4-(2-amino-1-hydroxyethyl)phenol as agonists of the BETA2 adrenergic receptor

A method of treating a pulmonary disease in a mammal comprising administering to the mammal a therapeutically effective amount of a pharmaceutical composition comprising a therapeutically effective amount of a compound of formula (I):

• wherein:
• R1 together with R2 form the group —NH—C(O)—CH═CH—, wherein the nitrogen atom is bound to the carbon atom in the phenyl ring holding R1 and the carbon atom is bound to the carbon atom in the phenyl ring holding R2;
• R3 is chosen from a hydrogen atom, halogen atoms, —SO—R5, —SO2—R5, —NH—CO—NH2, —CO—NH2, hydantoin, C1-4alkyl, C1-4alkoxy and —SO2NR5R6;
• R4 is chosen from a hydrogen atom, halogen atoms and C1-4 alkyl groups;
• R5 is chosen from C1-4 alkyl groups and C3-8 cycloalkyl groups;
• R6 is chosen from a hydrogen atom and C1-4 alkyl groups;
• n, p and q are each independently 0, 1, 2, 3 or 4;
• m and s are each independently 0, 1, 2 or 3;
• and
• r is 0, 1 or 2;
• with the provisos that:
• at least one of m and r is not 0
• the sum n+m+p+q+r+s is 7, 8, 9, 10, 11, 12 or 13
• the sum q+r+s is 2, 3, 4, 5 or 6
• or a pharmaceutically-acceptable salt or stereoisomer thereof.