11βhydroxysteroid dehydrogenase type 1
AssigneeBristol-Myers Squibb Company
InventorsDavid Gordon, Yuval Blat, Akbar Nayeem, Mark S. Kirby, Bin He
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Abstract
The invention provides gene-targeted non-human animals comprising a genetically modified 11βHSD1 gene encodes a mutant 11βHSD1 polypeptide which is modulated by human 11βHSD1 modulating compounds. The invention further provides cells expressing mutant 11βHSD1 and cells isolated from gene-targeted animals, which cells produce a mutant 11βHSD1. The invention further provides methods of identifying agents that modulate 11βHSD1 activity, and are useful to treat 11βHSD1-related metabolic disorders.
Claims2
An isolated nucleic acid molecule encoding a polypeptide of SEQ ID NO:
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An isolated nucleic acid molecule encoding a polypeptide of SEQ ID NO:
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Dependencies are inferred from the claim text.