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US 8,420,123 B2Granted
Drug loaded polymeric nanoparticles and methods of making and using same
AssigneeBind Biosciences, Inc.
InventorsGreg Troiano, Michael Figa, Abhimanyu Sabnis
Life of this patent
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Abstract
The present disclosure generally relates to methods of making nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic) acid-poly(ethylene)glycol.
Claims25
A method of preparing a plurality of therapeutic nanoparticles, comprising:
- combining a therapeutic agent, a first polymer, and optionally a second polymer, with an organic solvent to form a first organic phase having about 5 to about 50% solids;
- combining the first organic phase with a first aqueous solution to form a second phase;
- emulsifying the second phase to form an emulsion phase;
- quenching the emulsion phase to form a quenched phase;
- adding a drug solubilizer to the quenched phase to form a solubilized phase of unencapsulated therapeutic agent;
- and
- sterile filtering the solubilized phase to recover the therapeutic nanoparticles, thereby forming a slurry of therapeutic nanoparticles having a diameter of about 80 nm to about 150 nm.
4 more elements
Dependencies are inferred from the claim text.