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US 8,414,914 B2Granted
Compositions for mucosal delivery of agents
AssigneeVirun, Inc.
InventorsPhilip James Bromley, Lee Nickols Huang
Life of this patent
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Abstract
Compositions and methods for mucosal delivery of agents are provided. The compositions are intended for administration to mucosal surface, such as oral, gastrointestinal and nasal mucosa. The compositions provided contain one or more mucoadhesive proteins and an agent to be delivered. Methods for delivery of agents using the compositions provided herein are also provided.
Claims24
A composition, comprising:
- a mucoadhesive protein that is present at a concentration of about 1% by weight up to about 50% by weight of the total weight of the composition;
- an agent for delivery;
- and
- a delivery vehicle associated with the agent, wherein:
- the composition is formulated as an emulsion and is formulated for mucosal delivery to the oral or gastrointestinal tract mucosa;
- the mucoadhesive protein is associated with the delivery vehicle via a chemical or physical bond, whereby the composition adsorbs to the mucosa for effecting systemic delivery of the agent;
- the composition has a viscosity of about 50,000 cps up to 500,000 cps at about 72° F., whereby the composition is retained on a mucosal surface;
- and
- the delivery vehicle is selected from among a micelle, inverse micelle, liposome, cubosome and a mixture thereof.
6 more elements
A composition, comprising:
- a mucoadhesive protein present at a concentration of about 9% by weight up to about 10% by weight of the total weight of the composition;
- an agent for delivery;
- and
- a delivery vehicle associated with the agent;
- wherein:
- the composition is formulated for mucosal delivery to the oral or gastrointestinal mucosa or nasal or lung mucosa;
- the mucoadhesive protein is associated with the delivery vehicle;
- the mucoadhesive protein is associated with the delivery vehicle via a chemical or physical bond;
- and
- the delivery vehicle is selected from among a micelle, inverse micelle, liposome, cubosome and a mixture thereof.
7 more elements
A composition, comprising:
- a mucoadhesive protein that is present at a concentration of about 1% by weight up to about 50% by weight of the total weight of the composition;
- an agent for delivery;
- and
- a delivery vehicle associated with the agent, wherein:
- the composition is formulated as an emulsion and is formulated for mucosal delivery to the oral or gastrointestinal tract mucosa;
- the mucoadhesive protein is associated with the delivery vehicle via a chemical or physical bond, whereby the composition adsorbs to the mucosa for effecting systemic delivery of the agent;
- and
- the delivery vehicle is selected from among a micelle, inverse micelle, liposome, cubosome and a mixture thereof.
5 more elements
Dependencies are inferred from the claim text.