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US 8,412,504 B2Granted
System and method for high-content oncology assay
AssigneeRigel Pharmaceuticals, Inc.
InventorsSusan Catalano, John McLaughlin
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Abstract
The present invention provides an apparatus, system, method and computer program and computer program product for analyzing cellular samples. One embodiment of the apparatus and method provides a multiparameter assay that provides information with respect to cell proliferation, cell cycling and cell death. The multiparameter assay is particularly useful for assessing and screening candidate compounds for anti-cancer utility.
Claims8
A system for analyzing a sample comprising cells, comprising:
- an image capture device to gather luminescence intensity values of nuclei of cells stained with a fluorescent DNA-binding reporter molecule;
- and
- a computer connected to said image capture device, said computer including
- a peripheral interface circuit to receive said luminescence intensity values,
- a central processing unit connected to said peripheral interface circuit, and
- a memory connected to said central processing unit, said memory comprising executable instructions for:
- calculating the total nuclear fluorescence of each cell of a population of cells;
- and
- determining the cell phase of a cell in said cell population by its total nuclear fluorescence.
6 more elements
Dependencies are inferred from the claim text.