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AssigneeMicrosoft Corporation
InventorsRoland Stoughton, Timothy Hughes
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The invention relates to methods and systems (e.g., computer systems and computer program products) for characterizing cellular constituents, particularly genes and gene products. In particular, the invention provides methods for assigning or determining the biological function of uncharacterized genes and gene products by using “response profiles,” i.e., measurements of pluralities of cellular constituents in cells having a modified gene or gene product, as phenotypic markers for the gene or gene product. Methods are provided for clustering such response profiles so that similar or correlated response profiles are organized into the same cluster. The invention also provides databases or “compendiums” of response profiles to which the response profile of an uncharacterized gene or gene product can compared.
A method for characterizing a cellular constituent as being associated or not being associated with a biological function, said method comprises on a suitably programmed computer identifying one or more response profiles associated with a known biological function as either correlating or not correlating with a response profile for the cellular constituent being characterized, wherein:
A method for characterizing a cellular constituent as being associated or not associated with a particular biological function, in which said method comprises:
A computer system for characterizing cellular constituents, said computer system comprising:
A computer program product not consisting of a signal for use in conjunction with a computer having one or more memory units and one or more processor units, the computer program product comprising a computer readable storage medium having a computer program mechanism encoded thereon, wherein said computer program mechanism can be loaded into the one or more memory units of a computer and cause the one or more processor units of the computer to execute steps of:
Dependencies are inferred from the claim text.