Method for synthesis of secondary alcohols
AssigneeNational Tsing Hua University
InventorsChien-Hong Cheng, Jaganathan Karthikeyan, Pang-Chi Huang
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Abstract
A method for synthesis of secondary alcohols is provided for pharmaceutical secondary alcohol by addition of organoboronic acids with aldehydes in presence of the cobalt ion and bidentate ligands as the catalyst. In addition, an enantioselective synthesis method for secondary alcohols is also herein provided in the present invention. The present invention has advantages in using less expensive cobalt ion and commercially available chiral ligands as the catalyst, wide scope of organoboronic acids and aldehydes compatible with this catalytic reaction and achieving excellent yields and/or enantiomeric excess.
Claims20
A method for synthesis of secondary alcohols, comprising:
- reacting an organoboronic acid and an aldehyde in a reaction reagent to obtain a secondary alcohol, wherein the reaction reagent comprises a cobalt ion and a bidentate ligand.
An enantioselective method for synthesis of secondary alcohols, comprising:
- reacting an organoboronic acid and an aldehyde in an organic reagent to obtain an enantioselective secondary alcohol, wherein the organic reagent comprises a cobalt ion and a chiral bidentate ligand.
Dependencies are inferred from the claim text.