Method for preparing highly pure anhydrous crystalline docetaxel
AssigneeSamyang Genexbio Corporation
InventorsJin-Suk Cho, Moon-Suk Kim, Jai-Young Song, Jeong-Hwan Yun, Jong-Won Yoon, Ho-Joon Choi
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Abstract
A method for preparing highly pure anhydrous crystalline docetaxel is provided. The method for preparing highly pure anhydrous crystalline docetaxel enables preparation of anhydrous crystalline docetaxel that has purity of 99.5% or more, and is useful as an anticancer agent due to remarkably low residual solvent content compared to the standard of residual solvents in drugs.
Claims24
A method for preparing anhydrous crystalline docetaxel having purity of 99.5% or more comprising:
- (a) primarily purifying semi-synthesized docetaxel by low-pressure normal-phase chromatography;
- (b) secondarily purifying the primarily purified docetaxel by low-pressure reversed-phase chromatography;
- (c) adding acid in the concentration of 0.05%(v/v) to 10%(v/v) of docetaxel aliquot obtained after the secondary purification of docetaxcel of (b) to concentrate the secondarily purified docetaxel;
- and
- (d) recrystallizing the concentrated docetaxel of (c).
A method for preparing anhydrous crystalline docetaxel having purity of 99.5% or more comprising:
- (a) primarily purifying semi-synthesized docetaxel by low-pressure normal-phase chromatography;
- (b) secondarily purifying the primarily purified docetaxel by high-pressure reversed-phase chromatography;
- (c) adding acid in the concentration of 0.05%(v/v) to 10%(v/v) of docetaxel aliquot obtained after the secondary purification of docetaxcel of (b) to concentrate the secondarily purified docetaxel;
- and
- (d) recrystallizing the concentrated docetaxel of (c).
A method for preparing anhydrous crystalline docetaxel having purity of 99.5% or more comprising:
- (a) primarily purifying semi-synthesized docetaxel by low-pressure reversed-phase chromatography;
- (b) adding acid in the concentration of 0.05%(v/v) to 10%(v/v) of docetaxel aliquot obtained after the primary purification of docetaxcel of (a) to concentrate the primarily purified docetaxel
- (c) secondarily purifying the concentrated docetaxel by high-pressure normal-phase chromatography;
- and
- (d) recrystallizing the secondarily purified docetaxel.
Dependencies are inferred from the claim text.