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US 8,410,287 B2Granted
Hydrated sodium salt form of celecoxib
AssigneeMcNeil-PPC, Inc.
InventorsJulius F. Remenar, Mark D. Tawa, Matthew L. Peterson
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Abstract
Hydrated celecoxib sodium salt forms and processes to prepare hydrated celecoxib sodium salt forms are disclosed. The celecoxib sodium salt forms are particularly useful and suitable for pharmaceutical applications.
Claims2
A pentahydrate sodium salt form of celecoxib characterized by the powder x-ray diffraction pattern of FIG. 7.
A method of preparing a pentahydrate sodium salt form of celecoxib, comprising:
- dissolving celecoxib in 1.0 N NaOH;
- adding 0.3% benzyl alcohol;
- and
- allowing said pentahydrate sodium salt form of celecoxib to crystallize.
1 more element
Dependencies are inferred from the claim text.