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US 8,410,279 B2Granted
Substituted pyrroles and methods of use
AssigneeGenentech, Inc.
InventorsLewis J. Gazzard, Joseph Lyssikatos
Life of this patent
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Abstract
The invention relates to substituted pyrrole compounds of Formula (I) which are useful as kinase inhibitors, more specifically useful as checkpoint kinase 1 (chk1) inhibitors, thus useful as cancer therapeutics. The invention also relates to compositions, more specifically pharmaceutical compositions comprising these compounds and methods of using the same to treat various forms of cancer and hyperproliferative disorders, as well as methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
Claims11
A compound of Formula (I):
- R1 is phenyl or heteroaryl wherein said phenyl and heteroaryl is optionally substituted with one to five groups independently selected from halo, CN, and CF3;
- R2 is H;
- R3A and R3B are independently H, cycloalkyl, or heterocyclyl, wherein said cycloalkyl, and heterocyclyl are optionally substituted with one to five alkyl groups;
- X is O;
- and
- R4 is H, C1-C3 alkyl, C3-C5 cycloalkyl, wherein said alkyl is optionally substituted with one or more groups selected from OH, O(C1-C2 alkyl), fluoro and C3-C5 cycloalkyl;
- R5 is H.
4 more elements
Dependencies are inferred from the claim text.