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US 8,410,278 B2Granted
Method for preparing a non-hydratable crystal form
AssigneeE. I. Du Pont de Nemours and Company
InventorMatthew Richard Oberholzer
Life of this patent
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Abstract
A method is disclosed for preparing a non-hydratable crystal form from a hydratable crystal form of 3-bromo-1-(3-chloro-2-pyridinyl)-N-[4-cyano-2-methyl-6-[(methylamino)-carbonyl]phenyl]-1H-pyrazole-5-carboxamide (Compound 1).
Claims15
A method for preparing Polymorph A of 3-bromo-1-(3-chloro-2-pyridinyl)-N-[4-cyano-2-methyl-6-[(methylamino)carbonyl]phenyl]-1H-pyrazole-5-carboxamide characterized by a X-ray diffraction pattern having at least the 2θ reflection positions
- 2θ
- 6.78
- 11.09
- 19.94
- 20.99
- 26.57
- 26.98
- 31.52
- comprising heating at a temperature between about 40° C. and the boiling point of the solvent a mixture comprising a solvent selected from the group consisting of water, n-heptane, 1-chlorobutane, toluene, 1-butanol and 1-pentanol, and Polymorph B of 3-bromo-1-(3-chloro-2-pyridinyl)-N-[4-cyano-2-methyl-6-[(methylamino)carbonyl]phenyl]-1H-pyrazole-5-carboxamide characterized by a X-ray diffraction pattern having at least the 2θ reflection positions
- 2θ
- 7.43
- 9.89
- 18.68
- 19.36
- 22.16
- 23.09
- 25.70.
14 more elements
Dependencies are inferred from the claim text.