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US 8,410,250 B2Granted
Anti-FGFR3 antibodies and methods using same
AssigneeGenentech, Inc.
InventorsAvi Ashkenazi, Jing Qing, Christian Wiesmann, Yan Wu
Life of this patent
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Abstract
The invention provides FGFR3 antibodies, and compositions comprising and methods of using these antibodies.
Claims27
An isolated anti-FGFR3 antagonist antibody, wherein the antibody comprises:
- (i) a light chain variable region comprising (a) HVR-L1 comprising the amino acid sequence of SEQ ID NO:87, (b) HVR-L2 comprising the amino acid sequence of SEQ ID NO:88, and (c) HVR-L3 comprising the amino acid sequence of SEQ ID NO:89, and
- (ii) a heavy chain variable region comprising (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO:84, (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO:85, and (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO:86, wherein the antibody binds human FGFR3 with a Kd of 1×10−8M or stronger, and wherein the antibody inhibits dimerization of FGFR3 receptor with another unit of the receptor, whereby activation of the receptor is inhibited.
An isolated monoclonal anti-FGFR3 antibody, wherein the antibody comprises:
- (i) a light chain variable region comprising (a) HVR-L1 comprising the amino acid sequence of SEQ ID NO:87, (b) HVR-L2 comprising the amino acid sequence of SEQ ID NO:88, and (c) HVR-L3 comprising the amino acid sequence of SEQ ID NO:89, and
- a heavy chain variable region comprising (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO:84, (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO:85, and (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO:86.
Dependencies are inferred from the claim text.