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US 8,410,190 B2Granted
Wettable hydrogel materials for use in ophthalmic applications and methods
AssigneeCooperVision International Holding Company, LP
InventorsPeter Zhu, Ying Ye, Yun Zhang, Charlie Chen
Life of this patent
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Abstract
A contact lens is provided that has extended and rechargeable wettability. The contact lens includes a lens body that is a reaction product of a polymerizable composition. A first polyhydric alcohol having a 1,2 diol or 1,3 diol moiety is present on a lens surface of the lens body. A contact lens package including the contact lens, and methods of producing and using the contact lens, are also provided.
Claims22
A method of manufacturing a hydrogel contact lens body, comprising:
- (i) providing a polymerizable composition comprising
- at least one polymerizable form of a boronic acid, boronic ester, boronic anhydride, or combination thereof;
- at least one hydrophilic monomer, and
- at least one crosslinking agent;
- and
- (ii) cast molding the polymerizable composition in a contact lens mold assembly to form a polymerized reaction product that is an uncomplexed hydrogel lens body formed of a copolymer comprising
- polymerized units of the at least one polymerizable form of the boronic acid, boronic ester, boronic anhydride or combination thereof,
- polymerized units of the at least one hydrophilic monomer, and
- crosslinks formed by the at least one crosslinking agent;
- wherein the uncomplexed hydrogel lens body has
- an advancing contact angle less than about 120°,
- a modulus less than about 1.6 MPa,
- an ionoflux less than about 7×10−3 mm2/min.,
- an oxygen permeability of less than about 120 Barrers, and
- an equilibrium water content of at least about 30%.
12 more elements
A hydrogel lens body, comprising:
- a cast molded polymerized reaction product of a polymerizable composition reacted in a contact lens mold assembly to produce a hydrogel contact lens body, the polymerizable composition comprising
- at least one polymerizable form of a boronic acid, boronic ester, boronic anhydride, or combination thereof;
- at least one hydrophilic monomer;
- and
- at least one crosslinking agent;
- the hydrogel lens body formed of a copolymer comprising
- polymerized units of the at least one polymerizable form of the boronic acid, boronic ester, boronic anhydride or combination thereof,
- polymerized units of the at least one hydrophilic monomer, and
- crosslinks formed by the at least one crosslinking agent;
- wherein at least a portion of boronic acid moieties present in the copolymer of the lens body are complexed with a wetting agent, and the lens body is a complexed lens body, wherein an uncomplexed lens body has
- an advancing contact angle less than about 120°,
- a modulus less than about 1.6 MPa,
- an ionoflux less than about 7×10−3 mm2/min.,
- an oxygen permeability of less than about 120 Barrers, and
- an equilibrium water content of at least about 30%;
- and
- the complexed lens body has an advancing contact angle at least 10% less than an advancing contact angle of the uncomplexed lens body, as determined by testing hydrated lens bodies soaked in phosphate buffered saline for at least 6 hours.
14 more elements
Dependencies are inferred from the claim text.