Crosslinked polyalkyleneimine hydrogels with tunable degradation rates
AssigneeHyperBranch Medical Technology, Inc.
InventorsMichael A. Carnahan, Jared D. G. Butlin
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Abstract
One aspect of the present invention relates to methods of sealing a wound or tissue plane or filling a void space, or securing meshes, films or other devices within the body. In certain embodiments, the wound is an ophthalmic, pleural or dural wound, or a hernia repair mesh. Remarkably, disclosed herein is the discovery that the use of certain crosslinkers in combination with polyalkyleneimines at specific concentrations can result in hydrogels with tunable degradation properties.
Claims22
A polymeric composition, comprising an activated polyethylene glycol diacid derivative, and a covalent crosslinking agent;
- wherein the covalent crosslinking agent is polyethyleneimine having a weight average molecular weight of about 400 to about 2000 Daltons;
- the molar ratio of activated esters on the polyethylene glycol diacid derivative to primary amines on the polyethyleneimine is within a range of about 0.5:1 to about 1.5:1;
- and the activated polyethylene glycol diacid derivative is represented by formula I:
- wherein, independently for each occurrence,
- R is H;
- m is 5-10 inclusive;
- and w is 20 to 120 inclusive.
Dependencies are inferred from the claim text.