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US 8,410,180 B2Granted
Methods to treat urinary incontinence
AssigneeThe Cleveland Clinic Foundation
InventorsAnthony Calabro, Aniq B. Darr, Firouz Daneshgari
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AssigneeThe Cleveland Clinic Foundation
InventorsAnthony Calabro, Aniq B. Darr, Firouz Daneshgari
Estimating the term…
A method is disclosed for treatment of urinary incontinence. The method includes the steps of providing to a person or animal, in the vicinity of a pubo-urethral ligament of the person or animal, a composition including collagen macromolecules that have hydroxyphenyl side groups substituted thereon, which are reacted to form dihydroxyphenyl linkages. In an embodiment, the collagen macromolecules are gelatin macromolecules. In another embodiment, the hydroxyphenyl side groups are tyramine side groups and the dihydroxyphenyl linkages are dityramine linkages. The composition can be injected into a space between a urethra and a pubis of the person or animal wherein the pubo-urethral ligament is disposed in the space. The method is advantageous, for example, based on being minimally invasive.
A method of treating urinary incontinence comprising providing to a person or animal, in a space between a urethra and a pubis of the person or animal wherein the person's or animal's pubo-urethral ligament is disposed in the space, a composition comprising collagen macromolecules that have hydroxyphenyl side groups substituted thereon, at least a portion of said hydroxyphenyl side groups being reacted to form dihydroxyphenyl linkages.
A method of treating urinary incontinence comprising providing to a person or animal, in a space between a urethra and a pubis of the person or animal wherein the person's or animal's pubo-urethral ligament is disposed in the space, a composition comprising hydroxyphenyl-substituted macromolecules wherein at least a portion of said hydroxyphenyl side groups are reacted to form dihydroxyphenyl linkages, said macromolecules being selected from the group consisting of collagen, gelatin and hyaluronan.
Dependencies are inferred from the claim text.