Curcumin derivatives
AssigneeIndian Institute of Technology Bombay
InventorsIrishi N. N. Namboothiri, Narasimham Ayyagari, Deena Jose
Life of this patent
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Abstract
A compound has Formula VIII where, X is —C(O)R, —C(O)OR, —CN, —NO2, —S(O)2R′, —P(O)(OR)2; each R is individually H, alkyl, or alkenyl; R′ is alkyl or akenyl; R1 is aryl, alkenyl, arylalkenyl, heterocyclyl, or heteroaryl; and R2, R3, R4, R5, R6, R7, R8, R9, R10, and R11 are individually H, alkoxy, or hydroxy. In some cases, X is NO2. Pharmaceutical compositions of the compound of Formula VIII with a pharmaceutically acceptable carrier may be prepared. The compounds may be used for inhibition of cyclooxygenase-2.
Claims10
A compound of Formula VIII:
- wherein:
- X is —C(O)R, —C(O)OR, —CN, —NO2, —S(O)2R′, —P(O)(OR)2;
- each R is individually H, alkyl, aryl, or alkenyl;
- R′ is alkyl, aryl, or akenyl;
- R1 is aryl, alkenyl, arylalkenyl, heterocyclyl, or heteroaryl;
- and
- R2, R3, R4, R5, R6, R7, R8, R9, R10, and R11 are individually H, alkoxy, or hydroxy.
A method of preparing a compound of Formula VIII comprising:
- reacting a compound of Formula VI with a nitroalkene in the presence of a base, wherein:
- the nitroalkene has formula R1CH═CHNO2;
- R1 is aryl, alkene, heterocyclyl, or heteroaryl;
- and
- R2, R3, R4, R5, R6, R7, R8, R9, R10, and R11 are individually H, alkoxy, or hydroxy.
Dependencies are inferred from the claim text.