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US 8,410,164 B2Granted
Reagent for measurement of active oxygen
AssigneeThe University of Tokyo
InventorsTetsuo Nagano, Yasuteru Urano, Saki Izumi
Life of this patent
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Abstract
A compound represented by the formula (I) (R1 represents an aryl group such as hydroxyphenyl group, R2 represents 2-carboxyphenyl group etc., and R3 and R4 represent —(CH2)p—N(R5)(R6) (R5 and R6 represent —(CH2)n—COOH), a salt thereof, or an ester thereof, which is useful as a reagent for highly sensitive measurement of reactive oxygen such as hydroxy radical present at a trace amount in living bodies or tissues by a bioimaging technique over a long period of time.
Claims20
A compound represented by the following formula (I):
- wherein R1 represents an aryl group which may be substituted, R2 represents a 2-carboxyphenyl group which may be substituted, and R3 and R4 independently represent a group represented as —(CH2)p—N(R5)(R6) (in the formula, p represents an integer of 1 to 4, and R5 and R6 independently represent —(CH2)n—COOH (in the formula, n represents an integer of 1 to 4)), a salt thereof, or an ester thereof.
Dependencies are inferred from the claim text.