Choline esters
AssigneeEncore Health, LLC
InventorsWilliam Garner, Margaret Garner, George Minno, David Gooden
Life of this patent
Estimating the term…
Abstract
Compounds, formulations, and methods are provided containing the choline ester of a reducing agent, especially lipoic acid or derivatives thereof. The compounds may be administered via a topical ocular route to treat or prevent oxidative damage.
Claims26
A compound comprising a choline ester of lipoic acid or a derivative of lipoic acid, wherein the lipoic acid or derivative of lipoic acid is alpha lipoic acid, 6,8-dimercaptooctanoic acid, dihydrolipoate, 5-(1,2-thiaselenolan-5-yl)pentanoic acid or 5-(1,2-thiaselenolan-3-yl)pentanoic acid.
A pharmaceutical composition comprising an active agent that is a reducing agent-choline ester and at least one pharmaceutically acceptable excipient, wherein the reducing agent is alpha lipoic acid, 6,8-dimercaptooctanoic acid, dihydrolipoate, 5-(1,2-thiaselenolan-5-yl)pentanoic acid or 5-(1,2-thiaselenolan-3-yl)pentanoic acid.
A pharmaceutical composition comprising:
- about 0.25% to about 10% of a reducing agent-choline ester, optionally, about 0.05% to about 1.0% of a biochemical energy source, about 0.25% to about 1% buffer, about 0.2% to about 0.6% tonicity agent, and about 0.1% to about 0.4% viscosity agent, wherein the reducing agent is alpha lipoic acid, 6,8-dimercaptooctanoic acid, dihydrolipoate, 5-(1,2-thiaselenolan-5-yl)pentanoic acid or 5-(1,2-thiaselenolan-3-yl)pentanoic acid.
Dependencies are inferred from the claim text.