Aminomethyl benzene derivatives

A compound of formula (I)

• wherein
• A represents
• wherein the asterisks indicate the bond that is linked to the phenyl group bearing the substituents R1, R2 and R3;
• R1 represents —CH2—NR1aR1b, R2 represents hydrogen, and R3 represents hydrogen, C1-4 alkyl, or C1-3-alkoxy;
• or
• R1 represents —CH2—NR1aR1b, R2 represents C1-4-alkyl or C1-3-alkoxy, and R3 represents hydrogen or methyl;
• or
• R1 represents hydrogen, C1-4-alkyl or C1-3-alkoxy, R2 represents —CH2—NR2aR2b, and R3 represents hydrogen or methyl;
• R1a represents C1-4-alkyl,
• R1b represents hydrogen, or C1-2-alkyl, or R1a and R1b together with the nitrogen atom to which they are attached form a pyrrolidine ring;
• R2a represents C1-4-alkyl,
• R2b represents hydrogen, or C1-2-alkyl, or R2a and R2, together with the nitrogen atom to which they are attached form a pyrrolidine ring;
• R4 represents hydrogen, methyl, methoxy or chloro;
• R5 represents hydrogen, C1-3-alkyl, methoxy, fluoro or chloro;
• R6 represents 2,3-dihydroxypropyl, —CH2—(CH2)n—NR61R62, —CH2—(CH2)n—NHCOR64, —CH2—(CH2)n—NHSO2R63, —CH2—CH2—COOH, —CH2—CH2—CONR61R62, 1-(3-carboxy-azetidinyl)-3-propionyl, 1-(2-carboxy-pyrrolidinyl)-3-propionyl, 1-(3-carboxy-pyrrolidinyl)-3-propionyl, —CH2—CH(OH)—CH2—NR61R62, —CH2—CH(OH)—CH2—NHCOR64, —CH2—CH(OH)—CH2—NHSO2R63, hydroxy, hydroxy-C2-4-alkoxy, 1-hydroxymethyl-2-hydroxy-ethoxy, 2,3-dihydroxypropoxy, —OCH2—(CH2)m—NR61R62, —OCH2—(CH2)m—NHCOR64, —OCH2—(CH2)m—NHSO2R63, 2-[(azetidine-3-carboxylic acid)-1-yl]-ethoxy, 2-[(pyrrolidine-2-carboxylic acid)-1-yl]-ethoxy, 2-[(pyrrolidine-3-carboxylic acid)-1-yl]-ethoxy, —OCH2—CH(OH)—CH2—NR61R62, —OCH2—CH(OH)—CH2—NHCOR64, —OCH2—CH(OH)—CH2—NHSO2R63, 3-[(azetidine-3-carboxylic acid)-1-yl]-2-hydroxypropoxy, 2-hydroxy-3-[(pyrrolidine-2-carboxylic acid)-1-yl]-propoxy, 2-hydroxy-3-[(pyrrolidine-3-carboxylic acid)-1-yl]-propoxy, —NR61R62, —NHCO—R64;
• R61 represents hydrogen, methyl, ethyl, 2-hydroxyethyl, 3-hydroxypropyl, 2-aminoethyl, 2-(C1-4-alkylamino)ethyl, 2-(di-(C1-4-alkyl)amino)ethyl, carboxymethyl, (C1-4-alkylcarboxy)methyl, 2-carboxyethyl, or 2-(C1-4-alkylcarboxy)ethyl;
• R62 represents hydrogen or methyl;
• R63 represents methyl, ethyl, methylamino, or dimethylamino;
• R64 represents hydroxymethyl, 2-hydroxyethyl, methylaminomethyl, dimethylaminomethyl, or 2-methylamino-ethyl;
• m represents the integer 1 or 2;
• n represents 0, 1 or 2;
• and
• R7 represents hydrogen, or C1-2-alkyl;
• or a pharmaceutically acceptable salt thereof.