Method and composition for potentiating an opiate analgesic
AssigneeThe Board of Trustees of the University of Illinois
InventorAnil Gulati
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Abstract
Composition and methods of treating pain and reducing or reversing tolerance to opiate analgesics are disclosed. The composition and method utilize an opiate analgesic and an endothelin antagonist as active agents to treat pain in mammals, including humans.
Claims8
A method of treating symptoms of opiate analgesic withdrawal in an individual undergoing opiate analgesic therapy comprising administering a therapeutically effective amount of a specific endothelin-A antagonist, wherein the specific endothelin-A antagonist is BQ123, the opiate analgesic is selected from the group consisting of morphine, a salt thereof, and oxycodone hydrochloride, and the symptoms are selected from the group consisting of weight loss, nasal discharge, lacrimation, chills, enhanced motor reflexes, hyperthermia, hyperventilation, emesis and diarrhea.
Dependencies are inferred from the claim text.