Back to results
US 8,410,138 B2Granted
Compounds for activating TGF-beta signaling
AssigneesThe Board of Trustees of the Leland Stanford Junior University, SRI International
InventorsAnton Wyss-Coray, Mary J. Tanga
Life of this patent
Estimating the term…
Abstract
Compositions and methods for treatment and prevention of disorders and conditions characterized by reduced TGF-β signaling are described.
Claims16
A method for increasing TGF-β signaling activity in a mammalian subject comprising administering to the subject a compound corresponding to the formula:
- wherein:
- R4 is selected from the group consisting of thiophene, furan and cyclic alkyl;
- R5 is either piperidine or N-substituted piperidine, wherein the piperidine or N-substituted piperidine is attached to a urea nitrogen atom via an intervening alkylene group;
- and
- R6 is phenyl or substituted phenyl.
2 more elements
Dependencies are inferred from the claim text.