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US 8,410,133 B2Granted
Aminopyridines useful as inhibitors of protein kinases
AssigneeVertex Pharmaceuticals Incorporated
InventorsJuan-Miguel Jimenez, Philip Collier, Jeremy Green, Gregory Henkel, Michael Liu, Timothy Neuberger
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Abstract
The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds, the methods of using the aforementioned compounds, and compounds in the treatment of various diseases, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
Claims14
A compound of formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- Ht is I-c:
- wherein any substitutable carbon in ring I-c is optionally substituted with —R10;
- Ring D is phenyl, wherein the phenyl is optionally substituted with 1-5 —R5;
- Z1 is N;
- each RX, RY, and RZ is independently H, halo, or C1-6 aliphatic, wherein the aliphatic is optionally substituted with 1-5 groups selected from halo, —CN, and —OR;
- each R10 is independently selected from haloC1-6alkyl, C1-6 alkyl, halo, OR, C(═O)R, CO2R, COCOR, NO2, CN, S(O)R, SO2R, SR, N(R4)2, CON(R4)2, SO2N(R4)2, OC(═O)R, N(R4)COR, N(R4)CO2R;
- each R4 is independently selected from H, C1-6alkyl, or haloC1-6alkyl;
- each R5 is independently selected from halo, haloC1-6alkyl, C3-6 cycloalkyl, or C1-6alkyl;
- and
- each R is independently selected from H, C1-6alkyl, or haloC1-6alkyl.
8 more elements
Dependencies are inferred from the claim text.