Synthesis of 8H-3A-aza-cyclopenta [A ]indenes and 5,10-dihydropyrrolo[1,2-B]isoquinolines derivatives and their use as antitumor therapeutic agents

A compound of formula I, II, III, or IV:

• and pharmaceutically acceptable salts and mixtures thereof,
• wherein:
• R1 is chosen from hydrogen, a C1-C5 linear or branched alkyl group, an aryl, and a benzyl, which may be unsubstituted or substituted;
• R2, R3, R4 and R5 are independently chosen from hydrogen, C1-C6 alkyl, ORa, halo, cyano, nitro, NH2, NHRb, and N(Rb)2, wherein Ra is chosen from hydrogen and C1-C10 alkyl, and Rb is chosen from hydrogen and C1-C10 alkyl;
• and
• R6 is chosen from a saturated or unsaturated, linear or branched, C1-C5 alkyl group, an unsubstituted or substituted phenyl group, and an unsubstitued or substituted benzyl group,
• and further wherein:
• when the C1-C5 linear or branched alkyl group is substituted, one or more substituents are independently chosen from halogen, hydroxy, alkoxy, lower alkyl, lower alkenyl, and lower alkynyl;
• and
• when the aryl, the benzyl, or the phenyl group is substituted, one or more substituents are independently chosen from C1-C6 alkyl, ORa, halo, cyano, nitro, NH2, wherein Ra is as defined above.