Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts
AssigneeMetabolex, Inc.
InventorsJiangao Song, Charles A. McWherter, Fang Ma, Mark Andres, Igor Ivanisevic, Ekaterina Albert, Patricia Andres
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Abstract
Crystalline salts of 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine, compositions thereof, methods for their preparation, and methods for their use are disclosed.
Claims12
A crystalline salt of 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine selected from the group consisting of:
- besylate salt, which has substantially the same X-ray power diffraction (XRPD) pattern as shown in FIG. 15;
- camsylate salt, which has substantially the same X-ray power diffraction (XRPD) pattern as shown in FIG. 16;
- esylate salt, which has substantially the same X-ray power diffraction (XRPD) pattern as shown in FIG. 17;
- HBr salt, which has substantially the same X-ray power diffraction (XRPD) pattern as shown in FIG. 18;
- sulfate salt, which has substantially the same X-ray power diffraction (XRPD) pattern as shown in FIG. 20;
- tosylate salt, which has substantially the same X-ray power diffraction (XRPD) pattern as shown in FIG. 21;
- and
- HCl salt, which has substantially the same X-ray power diffraction (XRPD) pattern as shown in FIG. 22.
A crystalline HCl salt of 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine having substantially the same XRPD pattern as shown in FIG. 22.
A crystalline HCl salt of 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine that is a polymorph (Form I) having a XRPD pattern comprising peaks at degrees 2-theta diffraction angles of about 8.8, 10.8, 16.1, 17.4, 20.4, 20.9, 21.5, 21.7, 26.6, and 28.1.
A crystalline HCl salt of 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine that is a polymorph (Form II) having a XRPD pattern comprising peaks at degrees 2-theta diffraction angles of about 7.8, 10.1, 12.5, 18.4, 19.0, 20.8, 23.0, and 23.5.
Dependencies are inferred from the claim text.