Bicyclic heterocycle derivatives and methods of use thereof

A compound having the formula:

• or a pharmaceutically acceptable salt or stereoisomer thereof, wherein:
• R1 is cycloalkyl, which can be unsubstituted or optionally substituted with an alkyl or halo group;
• R2 is H, alkyl, halo or —O-alkyl;
• R3 is alkyl, cycloalkyl, aryl or heteroaryl, wherein any R3 group can be unsubstituted or optionally substituted with R4;
• each occurrence of R4 represents 1 to 4 substituents, which can be the same or different, and which are selected from alkyl, halo, —CN, —OR5, haloalkyl, aryl, heteroaryl, heterocycloalkyl, cycloalkyl, —N(R5)2, —S(O)2R6, —C(O)R5, —C(O)OR5 or —C(O)N(R5)2;
• each occurrence of R5 is independently H, alkyl or aryl;
• each occurrence of R6 is independently alkyl, aryl, haloalkyl, cycloalkyl, heterocycloalkyl or heteroaryl;
• each occurrence of R7 is independently H, alkyl, halo, —CN, —O-alkyl or haloalkyl;
• each occurrence of R8 is independently H or alkyl;
• J is —C(R7)— or —N—;
• K is —C(R7)— or —N—;
• L is —C(R7)— or —N—;
• Q is arylene or heteroarylene, each of which can be unsubstituted or optionally substituted with R4;
• W is a bond, alkylene, —C(O)—, —C(O)O—, —C(O)NH— or —S(O)2—;
• Y is alkylene, —O— or —N(R5)—;
• Z is alkylene, —O— or —N(R5)—;
• p is 0, 1 or 2;
• q is 1, 2 or 3, such that the sum of p and q is from 1 to 4;
• and
• each occurrence of t is independently 0 or 1.